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Genes 2015, 6(3), 607-621; doi:10.3390/genes6030607

Nucleosome Dancing at the Tempo of Histone Tail Acetylation

UMR CNRS 6286 UFIP, Université de Nantes, Epigénétique: Proliferation et Différenciation, 2 rue de Houssinière, 44322 Nantes Cedex 03, France
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Academic Editor: Jessica Tyler
Received: 7 May 2015 / Revised: 26 June 2015 / Accepted: 8 July 2015 / Published: 15 July 2015
(This article belongs to the Special Issue Chromatin Dynamics)
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Abstract

The impact of histone acetylation on transcription was revealed over 50 years ago by Allfrey and colleagues. However, it took decades for an understanding of the fine mechanism by which this posttranslational modification affects chromatin structure and promotes transcription. Here, we review breakthroughs linking histone tail acetylation, histone dynamics, and transcription. We also discuss the histone exchange during transcription and highlight the important function of a pool of non-chromatinized histones in chromatin dynamics. View Full-Text
Keywords: histone acetylation; transcription; chromatin dynamics histone acetylation; transcription; chromatin dynamics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Galvani, A.; Thiriet, C. Nucleosome Dancing at the Tempo of Histone Tail Acetylation. Genes 2015, 6, 607-621.

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