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Hints of tRNA-Derived Small RNAs Role in RNA Silencing Mechanisms
Laboratory of Functional Genomics, Institute Pasteur of Montevideo, Mataojo 2020, Montevideo 11400, Uruguay
Department of Medicine, Hospital de Clínicas, Av. Italia s/n, Montevideo 11400, Uruguay
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 24 August 2012; in revised form: 26 September 2012 / Accepted: 28 September 2012 / Published: 10 October 2012
Abstract: With the advent of new and improved high-throughput sequencing technologies in the last few years, a growing number of novel classes of small RNA, other than miRNAs or siRNA, has emerged, which appear as new actors in gene expression regulation. tRNA-derived small RNAs represent one of these novel members that are, surprisingly, among the most conserved class of small RNAs throughout evolution. They could represent the most primitive small RNA pathways from which the well-known canonical RNA silencing pathways reported in higher eukaryotes evolved. This review aims to make a compilation of the most relevant research literature in this field with the purpose of shedding light on the relation of these primitive tRNA-derived molecules with the gene silencing machinery.
Keywords: tRNAs; small RNAs; RNAi
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Garcia-Silva, M.R.; Cabrera-Cabrera, F.; Güida, M.C.; Cayota, A. Hints of tRNA-Derived Small RNAs Role in RNA Silencing Mechanisms. Genes 2012, 3, 603-614.
Garcia-Silva MR, Cabrera-Cabrera F, Güida MC, Cayota A. Hints of tRNA-Derived Small RNAs Role in RNA Silencing Mechanisms. Genes. 2012; 3(4):603-614.
Garcia-Silva, Maria Rosa; Cabrera-Cabrera, Florencia; Güida, Maria Catalina; Cayota, Alfonso. 2012. "Hints of tRNA-Derived Small RNAs Role in RNA Silencing Mechanisms." Genes 3, no. 4: 603-614.