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Genes 2012, 3(4), 603-614; doi:10.3390/genes3040603

Hints of tRNA-Derived Small RNAs Role in RNA Silencing Mechanisms

1,†,* , 1,†
, 1,†
 and 1,2
Received: 24 August 2012 / Revised: 26 September 2012 / Accepted: 28 September 2012 / Published: 10 October 2012
(This article belongs to the Special Issue RNA Interference)
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Abstract: With the advent of new and improved high-throughput sequencing technologies in the last few years, a growing number of novel classes of small RNA, other than miRNAs or siRNA, has emerged, which appear as new actors in gene expression regulation. tRNA-derived small RNAs represent one of these novel members that are, surprisingly, among the most conserved class of small RNAs throughout evolution. They could represent the most primitive small RNA pathways from which the well-known canonical RNA silencing pathways reported in higher eukaryotes evolved. This review aims to make a compilation of the most relevant research literature in this field with the purpose of shedding light on the relation of these primitive tRNA-derived molecules with the gene silencing machinery.
Keywords: tRNAs; small RNAs; RNAi tRNAs; small RNAs; RNAi
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Garcia-Silva, M.R.; Cabrera-Cabrera, F.; Güida, M.C.; Cayota, A. Hints of tRNA-Derived Small RNAs Role in RNA Silencing Mechanisms. Genes 2012, 3, 603-614.

AMA Style

Garcia-Silva MR, Cabrera-Cabrera F, Güida MC, Cayota A. Hints of tRNA-Derived Small RNAs Role in RNA Silencing Mechanisms. Genes. 2012; 3(4):603-614.

Chicago/Turabian Style

Garcia-Silva, Maria Rosa; Cabrera-Cabrera, Florencia; Güida, Maria Catalina; Cayota, Alfonso. 2012. "Hints of tRNA-Derived Small RNAs Role in RNA Silencing Mechanisms." Genes 3, no. 4: 603-614.

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