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Comparative Genomics of Erwinia amylovora and Related Erwinia Species—What do We Learn?
Department of Crop Sciences, University of Illinois at Urbana-Champaign, 1201 W. Gregory Dr., Urbana, IL 61801, USA
* Author to whom correspondence should be addressed.
Received: 7 August 2011; in revised form: 30 August 2011 / Accepted: 8 September 2011 / Published: 15 September 2011
Abstract: Erwinia amylovora, the causal agent of fire blight disease of apples and pears, is one of the most important plant bacterial pathogens with worldwide economic significance. Recent reports on the complete or draft genome sequences of four species in the genus Erwinia, including E. amylovora, E. pyrifoliae, E. tasmaniensis, and E. billingiae, have provided us near complete genetic information about this pathogen and its closely-related species. This review describes in silico subtractive hybridization-based comparative genomic analyses of eight genomes currently available, and highlights what we have learned from these comparative analyses, as well as genetic and functional genomic studies. Sequence analyses reinforce the assumption that E. amylovora is a relatively homogeneous species and support the current classification scheme of E. amylovora and its related species. The potential evolutionary origin of these Erwinia species is also proposed. The current understanding of the pathogen, its virulence mechanism and host specificity from genome sequencing data is summarized. Future research directions are also suggested.
Keywords: comparative genomics; in silico subtractive hybridization; type III secretion; effector; exopolysaccharide amylovoran; virulence; fire blight; apple; pear; Erwinia pyrifoliae
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Cite This Article
MDPI and ACS Style
Zhao, Y.; Qi, M. Comparative Genomics of Erwinia amylovora and Related Erwinia Species—What do We Learn? Genes 2011, 2, 627-639.
Zhao Y, Qi M. Comparative Genomics of Erwinia amylovora and Related Erwinia Species—What do We Learn? Genes. 2011; 2(3):627-639.
Zhao, Youfu; Qi, Mingsheng. 2011. "Comparative Genomics of Erwinia amylovora and Related Erwinia Species—What do We Learn?" Genes 2, no. 3: 627-639.