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Genes 2010, 1(3), 349-356; doi:10.3390/genes1030349

Review

Gene Conversion and Evolution of Gene Families: An Overview

Tomoko Ohta

National Institute of Genetics, Mishima, 411-8540, Japan

Received: 16 August 2010; in revised form: 27 September 2010 / Accepted: 28 September 2010 / Published: 30 September 2010

(This article belongs to the Special Issue Gene Conversion in Duplicated Genes)

Download PDF Full-Text [45 KB, uploaded 30 September 2010 12:43 CEST]

Abstract: The importance of gene conversion for the evolution of gene families is reviewed. Four problems concerning gene conversion, i.e., concerted evolution, generation of useful variation, deleterious effects, and relation to neofunctionalization, are discussed by surveying reported examples of evolving gene families. Emphasis is given toward understanding interactive effects of gene conversion and natural selection.

Keywords: interaction of gene conversion and selection; concerted evolution; generation of gene diversity

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