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Cells 2018, 7(7), 71; https://doi.org/10.3390/cells7070071

Centrosome Remodelling in Evolution

Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal
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Received: 26 May 2018 / Revised: 27 June 2018 / Accepted: 4 July 2018 / Published: 6 July 2018
(This article belongs to the Special Issue Comparative Biology of Centrosomal Structures in Eukaryotes)
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Abstract

The centrosome is the major microtubule organizing centre (MTOC) in animal cells. The canonical centrosome is composed of two centrioles surrounded by a pericentriolar matrix (PCM). In contrast, yeasts and amoebozoa have lost centrioles and possess acentriolar centrosomes—called the spindle pole body (SPB) and the nucleus-associated body (NAB), respectively. Despite the difference in their structures, centriolar centrosomes and SPBs not only share components but also common biogenesis regulators. In this review, we focus on the SPB and speculate how its structures evolved from the ancestral centrosome. Phylogenetic distribution of molecular components suggests that yeasts gained specific SPB components upon loss of centrioles but maintained PCM components associated with the structure. It is possible that the PCM structure remained even after centrosome remodelling due to its indispensable function to nucleate microtubules. We propose that the yeast SPB has been formed by a step-wise process; (1) an SPB-like precursor structure appeared on the ancestral centriolar centrosome; (2) it interacted with the PCM and the nuclear envelope; and (3) it replaced the roles of centrioles. Acentriolar centrosomes should continue to be a great model to understand how centrosomes evolved and how centrosome biogenesis is regulated. View Full-Text
Keywords: centrosome; centriole; spindle pole body; SPB; PCM; evolution centrosome; centriole; spindle pole body; SPB; PCM; evolution
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Ito, D.; Bettencourt-Dias, M. Centrosome Remodelling in Evolution. Cells 2018, 7, 71.

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