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Cells 2018, 7(5), 42; https://doi.org/10.3390/cells7050042

Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body

Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, 69120 Heidelberg, Germany
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Received: 19 April 2018 / Revised: 4 May 2018 / Accepted: 8 May 2018 / Published: 10 May 2018
(This article belongs to the Special Issue Comparative Biology of Centrosomal Structures in Eukaryotes)
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Abstract

The main microtubule organizing centre in the unicellular model organisms Saccharomyces cerevisiae and Schizosaccharomyces pompe is the spindle pole body (SPB). The SPB is a multilayer structure, which duplicates exactly once per cell cycle. Unlike higher eukaryotic cells, both yeast model organisms undergo mitosis without breakdown of the nuclear envelope (NE), a so-called closed mitosis. Therefore, in order to simultaneously nucleate nuclear and cytoplasmic MTs, it is vital to embed the SPB into the NE at least during mitosis, similarly to the nuclear pore complex (NPC). This review aims to embrace the current knowledge of the SPB duplication cycle with special emphasis on the critical step of the insertion of the new SPB into the NE. View Full-Text
Keywords: spindle pole body (SPB); nuclear pore complex (NPC); nuclear envelope (NE) insertion spindle pole body (SPB); nuclear pore complex (NPC); nuclear envelope (NE) insertion
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Rüthnick, D.; Schiebel, E. Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body. Cells 2018, 7, 42.

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