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Intra- and Intercellular Quality Control Mechanisms of Mitochondria

Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Shido 1314-1, Sanuki, Kagawa 769-2193, Japan
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Received: 30 November 2017 / Revised: 22 December 2017 / Accepted: 23 December 2017 / Published: 26 December 2017
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Abstract

Mitochondria function to generate ATP and also play important roles in cellular homeostasis, signaling, apoptosis, autophagy, and metabolism. The loss of mitochondrial function results in cell death and various types of diseases. Therefore, quality control of mitochondria via intra- and intercellular pathways is crucial. Intracellular quality control consists of biogenesis, fusion and fission, and degradation of mitochondria in the cell, whereas intercellular quality control involves tunneling nanotubes and extracellular vesicles. In this review, we outline the current knowledge on the intra- and intercellular quality control mechanisms of mitochondria. View Full-Text
Keywords: mitochondria; mitophagy; transmitophgy; PGC1; mitofusin; DRP1; MIRO1; CD38 mitochondria; mitophagy; transmitophgy; PGC1; mitofusin; DRP1; MIRO1; CD38
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Kiriyama, Y.; Nochi, H. Intra- and Intercellular Quality Control Mechanisms of Mitochondria. Cells 2018, 7, 1.

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