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Cells 2017, 6(3), 26; doi:10.3390/cells6030026

The Potential of Targeting Brain Pathology with Ascl1/Mash1

1
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore
2
NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117596, Singapore
Received: 15 August 2017 / Revised: 21 August 2017 / Accepted: 23 August 2017 / Published: 23 August 2017
View Full-Text   |   Download PDF [226 KB, uploaded 23 August 2017]

Abstract

The proneural factor Achaete-scute complex-like 1 (Ascl1/Mash1) acts as a pioneering transcription factor that initializes neuronal reprogramming. It drives neural progenitors and non-neuronal cells to exit the cell cycle, and promotes neuronal differentiation by activating neuronal target genes, even those that are normally repressed. Importantly, force-expression of Ascl1 was shown to drive proliferative reactive astroglia formed during stroke and glioblastoma stem cells towards neuronal differentiation, and this could potentially diminish CNS damage resulting from their proliferation. As a pro-neural factor, Ascl1 also has the general effect of enhancing neurite growth by damaged or surviving neurons. Here, a hypothesis that brain pathologies associated with traumatic/ischemic injury and malignancy could be targeted with pro-neural factors that drives neuronal differentiation is formulated and explored. Although a good number of caveats exist, exogenous over-expression of Ascl1, alone or in combination with other factors, may be worth further consideration as a therapeutic approach in brain injury and cancer. View Full-Text
Keywords: Achaete-scute complex-like 1 (Ascl1); glioblastoma; stroke Achaete-scute complex-like 1 (Ascl1); glioblastoma; stroke
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Tang, B.L. The Potential of Targeting Brain Pathology with Ascl1/Mash1. Cells 2017, 6, 26.

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