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Cells 2016, 5(1), 4; doi:10.3390/cells5010004

Feedback Regulation of Kinase Signaling Pathways by AREs and GREs

1
Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
2
Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota, Minneapolis, MN 55455, USA
3
Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Ritva Tikkanen
Received: 11 December 2015 / Revised: 20 January 2016 / Accepted: 20 January 2016 / Published: 25 January 2016
(This article belongs to the Special Issue Signal Transduction 2016)
View Full-Text   |   Download PDF [1197 KB, uploaded 25 January 2016]   |  

Abstract

In response to environmental signals, kinases phosphorylate numerous proteins, including RNA-binding proteins such as the AU-rich element (ARE) binding proteins, and the GU-rich element (GRE) binding proteins. Posttranslational modifications of these proteins lead to a significant changes in the abundance of target mRNAs, and affect gene expression during cellular activation, proliferation, and stress responses. In this review, we summarize the effect of phosphorylation on the function of ARE-binding proteins ZFP36 and ELAVL1 and the GRE-binding protein CELF1. The networks of target mRNAs that these proteins bind and regulate include transcripts encoding kinases and kinase signaling pathways (KSP) components. Thus, kinase signaling pathways are involved in feedback regulation, whereby kinases regulate RNA-binding proteins that subsequently regulate mRNA stability of ARE- or GRE-containing transcripts that encode components of KSP. View Full-Text
Keywords: posttranscriptional gene regulation; ARE- GRE- mRNA stability; CELF1; ELAVL1; ZFP36; kinase signaling posttranscriptional gene regulation; ARE- GRE- mRNA stability; CELF1; ELAVL1; ZFP36; kinase signaling
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Vlasova-St. Louis, I.; Bohjanen, P.R. Feedback Regulation of Kinase Signaling Pathways by AREs and GREs. Cells 2016, 5, 4.

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