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Cells 2016, 5(1), 2; doi:10.3390/cells5010002

Re-Use of Established Drugs for Anti-Metastatic Indications

1
MetaVì Labs Inc., 16238 Ranch Road 620 North, Suite F-347, Austin, TX 78717, USA
2
Faculty of Health—School of Medicine, Witten/Herdecke University, Alfred-Herrhausen-Straße 50, 58448 Witten, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Ritva Tikkanen
Received: 21 November 2015 / Revised: 4 January 2016 / Accepted: 8 January 2016 / Published: 12 January 2016
(This article belongs to the Special Issue Signal Transduction 2016)
View Full-Text   |   Download PDF [523 KB, uploaded 12 January 2016]   |  

Abstract

Most patients that die from cancer do not die due to the primary tumor but due to the development of metastases. However, there is currently still no drug on the market that specifically addresses and inhibits metastasis formation. This lack was, in the past, largely due to the lack of appropriate screening models, but recent developments have established such models and have provided evidence that tumor cell migration works as a surrogate for metastasis formation. Herein we deliver on several examples a rationale for not only testing novel cancer drugs by use of these screening assays, but also reconsider established drugs even of other fields of indication. View Full-Text
Keywords: cancer; metastasis; cell migration; drug screening cancer; metastasis; cell migration; drug screening
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Entschladen, F.; Thyssen, D.A.; Drell, D.W. Re-Use of Established Drugs for Anti-Metastatic Indications. Cells 2016, 5, 2.

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