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Cells 2015, 4(4), 622-630; doi:10.3390/cells4040622

Albumin and Furosemide Combination for Management of Edema in Nephrotic Syndrome: A Review of Clinical Studies

Department of Medicine, Rutgers New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
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Author to whom correspondence should be addressed.
Academic Editor: Christoph Englert
Received: 7 August 2015 / Revised: 29 September 2015 / Accepted: 30 September 2015 / Published: 7 October 2015
(This article belongs to the Special Issue The Kidney: Development, Disease and Regeneration)
View Full-Text   |   Download PDF [673 KB, uploaded 7 October 2015]

Abstract

The treatment of edema in patients with nephrotic syndrome is generally managed by dietary sodium restriction and loop diuretics. However, edema does not improve in some patients despite adequate sodium restriction and maximal dose of diuretics. In such patients, combination of albumin and a loop diuretic may improve edema by diuresis and natriuresis. The response to this combination of albumin and a diuretic has not been observed in all studies. The purpose of this review is to discuss the physiology of diuresis and natriuresis of this combination therapy, and provide a brief summary of various studies that have used albumin and a loop diuretic to improve diuretic-resistant edema. Also, the review suggests various reasons for not observing similar results by various investigators. View Full-Text
Keywords: nephrotic syndrome; albumin and diuretic; diuresis; natriuresis; edema management nephrotic syndrome; albumin and diuretic; diuresis; natriuresis; edema management
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Duffy, M.; Jain, S.; Harrell, N.; Kothari, N.; Reddi, A.S. Albumin and Furosemide Combination for Management of Edema in Nephrotic Syndrome: A Review of Clinical Studies. Cells 2015, 4, 622-630.

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