Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination
AbstractTGF-β(transforming growth factor-β) superfamily signaling mediators are important regulators of diverse physiological and pathological events. TGF-β signals are transduced by transmembrane type I and type II serine/threonine kinase receptors and their downstream effectors, the SMAD(drosophila mothers against decapentaplegic protein) proteins. Numerous studies have already demonstrated crucial regulatory roles for modification of TGF-β pathway components by poly-ubiquitination. Recently, several studies also uncovered mono-ubiquitination of SMADs as a mechanism for SMAD activation or inactivation. Mono-ubiquitination and subsequent deubiquitination of SMAD proteins accordingly play important roles in the control of TGF-β superfamily signaling. This review highlights the major pathways regulated by SMAD mono-ubiquitination. View Full-Text
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Xie, F.; Zhang, Z.; van Dam, H.; Zhang, L.; Zhou, F. Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination. Cells 2014, 3, 981-993.
Xie F, Zhang Z, van Dam H, Zhang L, Zhou F. Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination. Cells. 2014; 3(4):981-993.Chicago/Turabian Style
Xie, Feng; Zhang, Zhengkui; van Dam, Hans; Zhang, Long; Zhou, Fangfang. 2014. "Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination." Cells 3, no. 4: 981-993.