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Correction: Sadofsky, L.R., et al. Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells. Cells 2014, 3, 616-626
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Cells 2014, 3(4), 1089-1101; doi:10.3390/cells3041089

Natural and Synthetic Modulators of the TRPM7 Channel

Walther Straub Institute of Pharmacology and Toxicology, University of Munich, Goethestrasse 33, 80336 Munich, Germany.
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Received: 26 September 2014 / Revised: 19 November 2014 / Accepted: 20 November 2014 / Published: 27 November 2014
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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Abstract

Transient receptor potential cation channel subfamily M member 7 (TRPM7) is a bi-functional protein comprising a TRP ion channel segment linked to an α-type protein kinase domain. Genetic inactivation of TRPM7 revealed its central role in magnesium metabolism, cell motility, proliferation and differentiation. TRPM7 is associated with anoxic neuronal death, cardiac fibrosis and tumor progression highlighting TRPM7 as a new drug target. Recently, several laboratories have independently identified pharmacological compounds inhibiting or activating the TRPM7 channel. The recently found TRPM7 modulators were used as new experimental tools to unravel cellular functions of the TRPM7 channel. Here, we provide a concise overview of this emerging field. View Full-Text
Keywords: TRPM7; TRPM6; TRP channel; α-kinase; magnesium; calcium TRPM7; TRPM6; TRP channel; α-kinase; magnesium; calcium
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chubanov, V.; Schäfer, S.; Ferioli, S.; Gudermann, T. Natural and Synthetic Modulators of the TRPM7 Channel. Cells 2014, 3, 1089-1101.

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