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Cells 2014, 3(3), 674-689; doi:10.3390/cells3030674
Review

Mechanisms of Generating Polyubiquitin Chains of Different Topology

1, 2, 2 and 2,3,*
Received: 13 May 2014; in revised form: 11 June 2014 / Accepted: 19 June 2014 / Published: 1 July 2014
(This article belongs to the Special Issue Protein Ubiquitination)
View Full-Text   |   Download PDF [940 KB, uploaded 1 July 2014]
Abstract: Ubiquitination is an important post-translational process involving attachment of the ubiquitin molecule to lysine residue/s on a substrate protein or on another ubiquitin molecule, leading to the formation of protein mono-, multi- or polyubiquitination. Protein ubiquitination requires a cascade of three enzymes, where the interplay between different ubiquitin-conjugating and ubiquitin-ligase enzymes generates diverse ubiquitinated proteins topologies. Structurally diverse ubiquitin conjugates are recognized by specific proteins with ubiquitin-binding domains (UBDs) to target the substrate proteins of different pathways. The mechanism/s for generating the different ubiquitinated proteins topologies is not well understood. Here, we will discuss our current understanding of the mechanisms underpinning the generation of mono- or polyubiquitinated substrates. In addition, we will discuss how linkage-specific polyubiquitin chains through lysines-11, -48 or -63 are formed to target proteins to different fates by binding specific UBD proteins.
Keywords: protein ubiquitination; ubiquitin chain topologies; polyubiquitination protein ubiquitination; ubiquitin chain topologies; polyubiquitination
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Suryadinata, R.; Roesley, S.N.A.; Yang, G.; Šarčević, B. Mechanisms of Generating Polyubiquitin Chains of Different Topology. Cells 2014, 3, 674-689.

AMA Style

Suryadinata R, Roesley SNA, Yang G, Šarčević B. Mechanisms of Generating Polyubiquitin Chains of Different Topology. Cells. 2014; 3(3):674-689.

Chicago/Turabian Style

Suryadinata, Randy; Roesley, Siti N.A.; Yang, George; Šarčević, Boris. 2014. "Mechanisms of Generating Polyubiquitin Chains of Different Topology." Cells 3, no. 3: 674-689.


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