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Cells 2014, 3(3), 674-689; doi:10.3390/cells3030674
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Mechanisms of Generating Polyubiquitin Chains of Different Topology

1, 2, 2 and 2,3,*
1 CSIRO Materials Science and Engineering, Parkville, Victoria 3052, Australia 2 Cell Cycle and Cancer Unit, St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia 3 Department of Medicine, St. Vincent's Hospital, University of Melbourne, Fitzroy, Victoria 3065, Australia
* Author to whom correspondence should be addressed.
Received: 13 May 2014 / Revised: 11 June 2014 / Accepted: 19 June 2014 / Published: 1 July 2014
(This article belongs to the Special Issue Protein Ubiquitination)
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Abstract

Ubiquitination is an important post-translational process involving attachment of the ubiquitin molecule to lysine residue/s on a substrate protein or on another ubiquitin molecule, leading to the formation of protein mono-, multi- or polyubiquitination. Protein ubiquitination requires a cascade of three enzymes, where the interplay between different ubiquitin-conjugating and ubiquitin-ligase enzymes generates diverse ubiquitinated proteins topologies. Structurally diverse ubiquitin conjugates are recognized by specific proteins with ubiquitin-binding domains (UBDs) to target the substrate proteins of different pathways. The mechanism/s for generating the different ubiquitinated proteins topologies is not well understood. Here, we will discuss our current understanding of the mechanisms underpinning the generation of mono- or polyubiquitinated substrates. In addition, we will discuss how linkage-specific polyubiquitin chains through lysines-11, -48 or -63 are formed to target proteins to different fates by binding specific UBD proteins.
Keywords: protein ubiquitination; ubiquitin chain topologies; polyubiquitination protein ubiquitination; ubiquitin chain topologies; polyubiquitination
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Suryadinata, R.; Roesley, S.N.A.; Yang, G.; Šarčević, B. Mechanisms of Generating Polyubiquitin Chains of Different Topology. Cells 2014, 3, 674-689.

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