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Cells 2014, 3(3), 662-673; doi:10.3390/cells3030662

TRPV Channels in Mast Cells as a Target for Low-Level-Laser Therapy

Shanghai University of Traditional Chinese Medicine and Shanghai Research Center for Acupuncture and Meridians, Shanghai 201203, China
Department of Mechanics and Engineering Science, Fudan University Shanghai, Shanghai 201203, China
Institute for Biophysics, Goethe-University Frankfurt am Main, 60438 Frankfurt, Germany
Author to whom correspondence should be addressed.
Received: 5 May 2014 / Revised: 9 June 2014 / Accepted: 17 June 2014 / Published: 26 June 2014
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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Low-level laser irradiation in the visible as well as infrared range is applied to skin for treatment of various diseases. Here we summarize and discuss effects of laser irradiation on mast cells that leads to degranulation of the cells. This process may contribute to initial steps in the final medical effects. We suggest that activation of TRPV channels in the mast cells forms a basis for the underlying mechanisms and that released ATP and histamine may be putative mediators for therapeutic effects. View Full-Text
Keywords: laser light; TRPV activation; mast-cell degranulation; ATP; Ca2+; histamine laser light; TRPV activation; mast-cell degranulation; ATP; Ca2+; histamine

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wang, L.; Zhang, D.; Schwarz, W. TRPV Channels in Mast Cells as a Target for Low-Level-Laser Therapy. Cells 2014, 3, 662-673.

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