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Cells 2014, 3(2), 455-475; doi:10.3390/cells3020455
Review

Physiological Function and Characterization of TRPCs in Neurons

1, 1, 2 and 1,*
Received: 21 March 2014; in revised form: 22 April 2014 / Accepted: 13 May 2014 / Published: 21 May 2014
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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Abstract: Ca2+ entry is essential for regulating vital physiological functions in all neuronal cells. Although neurons are engaged in multiple modes of Ca2+ entry that regulates variety of neuronal functions, we will only discuss a subset of specialized Ca2+-permeable non-selective Transient Receptor Potential Canonical (TRPC) channels and summarize their physiological and pathological role in these excitable cells. Depletion of endoplasmic reticulum (ER) Ca2+ stores, due to G-protein coupled receptor activation, has been shown to activate TRPC channels in both excitable and non-excitable cells. While all seven members of TRPC channels are predominately expressed in neuronal cells, the ion channel properties, mode of activation, and their physiological responses are quite distinct. Moreover, many of these TRPC channels have also been suggested to be associated with neuronal development, proliferation and differentiation. In addition, TRPCs also regulate neurosecretion, long-term potentiation and synaptic plasticity. Similarly, perturbations in Ca2+ entry via the TRPC channels have been also suggested in a spectrum of neuropathological conditions. Hence, understanding the precise involvement of TRPCs in neuronal function and in neurodegenerative conditions would presumably unveil avenues for plausible therapeutic interventions for these devastating neuronal diseases.
Keywords: Ca2+; TRPC channels; neuronal function; neurodegenerative diseases Ca2+; TRPC channels; neuronal function; neurodegenerative diseases
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sun, Y.; Sukumaran, P.; Bandyopadhyay, B.C.; Singh, B.B. Physiological Function and Characterization of TRPCs in Neurons. Cells 2014, 3, 455-475.

AMA Style

Sun Y, Sukumaran P, Bandyopadhyay BC, Singh BB. Physiological Function and Characterization of TRPCs in Neurons. Cells. 2014; 3(2):455-475.

Chicago/Turabian Style

Sun, Yuyang; Sukumaran, Pramod; Bandyopadhyay, Bidhan C.; Singh, Brij B. 2014. "Physiological Function and Characterization of TRPCs in Neurons." Cells 3, no. 2: 455-475.



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