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Polymers 2017, 9(12), 717; https://doi.org/10.3390/polym9120717

Preparation of Copolymer-Based Nanoparticles with Broad-Spectrum Antimicrobial Activity

1
Guangxi Key Lab of Petrochemical Resource Processing and Process Intensification Technology, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China
2
College of Petroleum and Chemical Engineering, Qinzhou University, Qinzhou 535006, China
3
Department of Chemical Engineering, University of New Brunswick, Fredericton, NB E3B 5A3, Canada
*
Author to whom correspondence should be addressed.
Received: 31 October 2017 / Revised: 1 December 2017 / Accepted: 10 December 2017 / Published: 15 December 2017
(This article belongs to the Special Issue Antimicrobial Polymers)
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Abstract

Polyacrylate and guanidine-based nanoparticles which involve acrylate monomers and glycidyl methacrylate modified oligo-guanidine were prepared by a seeded semi-continuous emulsion polymerization. The results from transmission electron microscope and dynamic light scattering measurements showed that the nanoparticles were spherical in shape and the particle size was in the range of 80–130 nm. Antimicrobial experiments were performed with two types of bacteria, Gram-negative (Escherichia coli, ATCC 8739) and Gram-positive (Staphylococcus aureus, ATCC 6538). The as-synthesized cationic nanoparticles exhibited effective antimicrobial activities on Escherichia coli and Staphylococcus aureus with the minimal inhibitory concentrations at 8 μg/mL and 4 μg/mL, respectively. The mechanism of action of the resulted nanoparticles against these bacteria was revealed by the scanning electron microscopic observation. In addition, the films consisting of latex nanoparticles are non-leaching antimicrobial materials with excellent antimicrobial activity, which indicates the polymers could preserve their antimicrobial activity for long-term effectiveness. View Full-Text
Keywords: antimicrobial activity; nanoparticles; tailor-modified; guanidine-based; scanning electron microscope antimicrobial activity; nanoparticles; tailor-modified; guanidine-based; scanning electron microscope
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Li, Y.; Cai, P.; Tong, Z.-F.; Xiao, H.; Pan, Y. Preparation of Copolymer-Based Nanoparticles with Broad-Spectrum Antimicrobial Activity. Polymers 2017, 9, 717.

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