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Erratum published on 12 March 2018, see Polymers 2018, 10(3), 304.

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Polymers 2017, 9(12), 638; https://doi.org/10.3390/polym9120638

A Novel Human-Like Collagen Hydrogel Scaffold with Porous Structure and Sponge-Like Properties

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Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, 229 North Taibai Road, Xi’an 710069, China
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Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, 229 North Taibai Road, Xi’an 710069, China
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Authors to whom correspondence should be addressed.
Received: 17 October 2017 / Revised: 10 November 2017 / Accepted: 16 November 2017 / Published: 13 December 2017
(This article belongs to the Special Issue Hydrogels in Tissue Engineering and Regenerative Medicine)
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Abstract

The aim of this research was to prepare a novel sponge-like porous hydrogel scaffold based on human-like collagen (HLC) that could be applied in cartilage tissue regeneration. In this study, bovine serum albumin (BSA) was used as a porogen to prepare the porous hydrogel, which had not been previously reported. Glutamine transaminase (TGase) was used as the cross-linker of the hydrogel, because it could catalyze the cross-linking of BSA. During the crosslinking process, BSA and HLC were mixed together, which affected the cross-linking of HLC. When the cross-linking was completed, the non-crosslinked section formed pores. The microstructure, porosity, swelling properties, and compressive properties of the hydrogel were studied. The results showed that the pore size of the hydrogel was between 100 and 300 μm, the porosity reached up to 93.43%, and the hydrogel had rapid water absorption and suitable mechanical properties. Finally, we applied the hydrogel to cartilage tissue engineering through in vitro and in vivo research. The in vitro cell experiments suggested that the hydrogel could promote the proliferation and adhesion of chondrocytes, and in vivo transplantation of the hydrogel could enhance the repair of cartilage. In general, the hydrogel is promising as a tissue engineering scaffold for cartilage. View Full-Text
Keywords: human-like collagen; sponge-like; porous hydrogel; cartilage tissue engineering; biological cross-linker human-like collagen; sponge-like; porous hydrogel; cartilage tissue engineering; biological cross-linker
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Song, X.; Zhu, C.; Fan, D.; Mi, Y.; Li, X.; Fu, R.Z.; Duan, Z.; Wang, Y.; Feng, R.R. A Novel Human-Like Collagen Hydrogel Scaffold with Porous Structure and Sponge-Like Properties. Polymers 2017, 9, 638.

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