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Polymers 2017, 9(11), 589; https://doi.org/10.3390/polym9110589

Blood Compatibility of ZrO2 Particle Reinforced PEEK Coatings on Ti6Al4V Substrates

1
State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China
2
Biomechanics and Biotechnology Lab, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, China
3
Department of Osteology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China
*
Authors to whom correspondence should be addressed.
Received: 1 October 2017 / Revised: 30 October 2017 / Accepted: 6 November 2017 / Published: 10 November 2017
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Abstract

Titanium (Ti) and its alloys are widely used in biomedical devices. As biomaterials, the blood compatibility of Ti and its alloys is important and needs to be further improved to provide better functionality. In this work, we studied the suitability of zirconia (ZrO2) particle reinforced poly-ether-ether-ketone (PEEK) coatings on Ti6Al4V substrates for blood-contacting implants. The wettability, surface roughness and elastic modulus of the coatings were examined. Blood compatibility tests were conducted by erythrocytes observation, hemolysis assay and clotting time of recalcified human plasma, to find out correlations between the microstructure of the ZrO2-filled PEEK composite coatings and their blood compatibilities. The results suggested that adding ZrO2 nanoparticles increased the surface roughness and improved the wettability and Derjaguin-Muller-Toporov (DMT) elastic modulus of PEEK coating. The PEEK composite matrix coated Ti6Al4V specimens did not cause any aggregation of erythrocytes, showing morphological normal shapes. The hemolysis rate (HR) values of the tested specimens were much less than 5% according to ISO 10993-4 standard. The values of plasma recalcification time (PRT) of the tested specimens varied with the increasing amount of ZrO2 nanoparticles. Based on the results obtained, 10 wt % ZrO2 particle reinforced PEEK coating has demonstrated an optimum blood compatibility, and can be considered as a candidate to improve the performance of existing PEEK based coatings on titanium substrates. View Full-Text
Keywords: blood compatibility; PEEK; zirconia (ZrO2); coating blood compatibility; PEEK; zirconia (ZrO2); coating
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Song, J.; Liao, Z.; Shi, H.; Xiang, D.; Xu, L.; Liu, Y.; Mu, X.; Liu, W. Blood Compatibility of ZrO2 Particle Reinforced PEEK Coatings on Ti6Al4V Substrates. Polymers 2017, 9, 589.

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