Next Article in Journal
Precise Synthesis of Macromolecular Architectures by Novel Iterative Methodology Combining Living Anionic Polymerization with Specially Designed Linking Chemistry
Next Article in Special Issue
Ferrocene-Modified Block Copolymers for the Preparation of Smart Porous Membranes
Previous Article in Journal
pH-Mediated Antibacterial Dyeing of Cotton with Prodigiosins Nanomicelles Produced by Microbial Fermentation
Previous Article in Special Issue
Preparation and Characterization of Thermo-Responsive Rod-Coil Diblock Copolymers
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessArticle
Polymers 2017, 9(10), 469; doi:10.3390/polym9100469

Fabrication of Hypericin Imprinted Polymer Nanospheres via Thiol-Yne Click Reaction

Shanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi, China
Authors to whom correspondence should be addressed.
Received: 31 August 2017 / Revised: 20 September 2017 / Accepted: 21 September 2017 / Published: 24 September 2017
(This article belongs to the Special Issue Polymers and Block Copolymers at Interfaces and Surfaces)
View Full-Text   |   Download PDF [2742 KB, uploaded 25 September 2017]   |  


To fabricate molecularly imprinted polymer nanospheres via click reaction, five different clickable compounds were synthesized and two types of click reactions (azide-alkyne and thiol-yne) were explored. It was found that molecularly imprinted polymer nanospheres could be successfully synthesized via thiol-yne click reaction using 3,5-diethynyl-pyridine (1) as the monomer, tris(3-mercaptopropionate) (tri-thiol, 5) as the crosslinker, and hypericin as the template (MIP–NSHs). The click polymerization completed in merely 4 h to produce the desired MIP–NSHs, which were characterized by FTIR, SEM, DLS, and BET, respectively. The reaction conditions for adsorption capacity and selectivity towards hypericin were optimized, and the MIP–NSHs synthesized under the optimized conditions showed a high adsorption capacity (Q = 6.03 μmol•g−1) towards hypericin. The imprinting factors of MIP–NSHs towards hypericin, protohypericin, and emodin were 2.44, 2.88, and 2.10, respectively. View Full-Text
Keywords: molecular imprinting; hypericin; click reaction; nanospheres molecular imprinting; hypericin; click reaction; nanospheres

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Pei, Y.; Fan, F.; Wang, X.; Feng, W.; Hou, Y.; Pei, Z. Fabrication of Hypericin Imprinted Polymer Nanospheres via Thiol-Yne Click Reaction. Polymers 2017, 9, 469.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top