Fabrication of Hypericin Imprinted Polymer Nanospheres via Thiol-Yne Click Reaction
AbstractTo fabricate molecularly imprinted polymer nanospheres via click reaction, five different clickable compounds were synthesized and two types of click reactions (azide-alkyne and thiol-yne) were explored. It was found that molecularly imprinted polymer nanospheres could be successfully synthesized via thiol-yne click reaction using 3,5-diethynyl-pyridine (1) as the monomer, tris(3-mercaptopropionate) (tri-thiol, 5) as the crosslinker, and hypericin as the template (MIP–NSHs). The click polymerization completed in merely 4 h to produce the desired MIP–NSHs, which were characterized by FTIR, SEM, DLS, and BET, respectively. The reaction conditions for adsorption capacity and selectivity towards hypericin were optimized, and the MIP–NSHs synthesized under the optimized conditions showed a high adsorption capacity (Q = 6.03 μmol•g−1) towards hypericin. The imprinting factors of MIP–NSHs towards hypericin, protohypericin, and emodin were 2.44, 2.88, and 2.10, respectively. View Full-Text
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Pei, Y.; Fan, F.; Wang, X.; Feng, W.; Hou, Y.; Pei, Z. Fabrication of Hypericin Imprinted Polymer Nanospheres via Thiol-Yne Click Reaction. Polymers 2017, 9, 469.
Pei Y, Fan F, Wang X, Feng W, Hou Y, Pei Z. Fabrication of Hypericin Imprinted Polymer Nanospheres via Thiol-Yne Click Reaction. Polymers. 2017; 9(10):469.Chicago/Turabian Style
Pei, Yuxin; Fan, Fengfeng; Wang, Xinxin; Feng, Weiwei; Hou, Yong; Pei, Zhichao. 2017. "Fabrication of Hypericin Imprinted Polymer Nanospheres via Thiol-Yne Click Reaction." Polymers 9, no. 10: 469.
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