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Polymers 2016, 8(6), 227; doi:10.3390/polym8060227

Polyglycidol, Its Derivatives, and Polyglycidol-Containing Copolymers—Synthesis and Medical Applications

Center of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland
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Academic Editor: Jianxun Ding
Received: 9 May 2016 / Revised: 30 May 2016 / Accepted: 31 May 2016 / Published: 9 June 2016
(This article belongs to the Special Issue Functional Polymers for Medical Applications)

Abstract

Polyglycidol (or polyglycerol) is a biocompatible polymer with a main chain structure similar to that of poly(ethylene oxide) but with a –CH2OH reactive side group in every structural unit. The hydroxyl groups in polyglycidol not only increase the hydrophilicity of this polymer but also allow for its modification, leading to polymers with carboxyl, amine, and vinyl groups, as well as to polymers with bonded aliphatic chains, sugar moieties, and covalently immobilized bioactive compounds in particular proteins. The paper describes the current state of knowledge on the synthesis of polyglycidols with various topology (linear, branched, and star-like) and with various molar masses. We provide information on polyglycidol-rich surfaces with protein-repelling properties. We also describe methods for the synthesis of polyglycidol-containing copolymers and the preparation of nano- and microparticles that could be derived from these copolymers. The paper summarizes recent advances in the application of polyglycidol and polyglycidol-containing polymers as drug carriers, reagents for diagnostic systems, and elements of biosensors. View Full-Text
Keywords: polyglycidol; linear; branched; copolymer; nanoparticles; microparticles; carriers of bioactive compounds polyglycidol; linear; branched; copolymer; nanoparticles; microparticles; carriers of bioactive compounds
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gosecki, M.; Gadzinowski, M.; Gosecka, M.; Basinska, T.; Slomkowski, S. Polyglycidol, Its Derivatives, and Polyglycidol-Containing Copolymers—Synthesis and Medical Applications. Polymers 2016, 8, 227.

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