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Polymers 2016, 8(6), 218; doi:10.3390/polym8060218

Poly(lactide-co-glycolide)/Hydroxyapatite Porous Scaffold with Microchannels for Bone Regeneration

1
Department of Foot and Ankle Surgery, The Second Hospital of Shandong University, Jinan 250033, China
2
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130021, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Carsten Werner
Received: 7 April 2016 / Revised: 6 May 2016 / Accepted: 30 May 2016 / Published: 7 June 2016
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Abstract

Mass transfer restrictions of scaffolds are currently hindering the development of three-dimensional (3D), clinically viable, and tissue-engineered constructs. For this situation, a 3D poly(lactide-co-glycolide)/hydroxyapatite porous scaffold, which was very favorable for the transfer of nutrients to and waste products from the cells in the pores, was developed in this study. The 3D scaffold had an innovative structure, including macropores with diameters of 300–450 μm for cell ingrowth and microchannels with diameters of 2–4 μm for nutrition and waste exchange. The mechanical strength in wet state was strong enough to offer structural support. The typical structure was more beneficial for the attachment, proliferation, and differentiation of rabbit bone marrow mesenchymal stem cells (rBMSCs). The alkaline phosphatase (ALP) activity and calcium (Ca) deposition were evaluated on the differentiation of rBMSCs, and the results indicated that the microchannel structure was very favorable for differentiating rBMSCs into maturing osteoblasts. For repairing rabbit radius defects in vivo, there was rapid healing in the defects treated with the 3D porous scaffold with microchannels, where the bridging by a large bony callus was observed at 12 weeks post-surgery. Based on the results, the 3D porous scaffold with microchannels was a promising candidate for bone defect repair. View Full-Text
Keywords: poly(lactide-co-glycolide); hydroxyapatite; porous scaffold; microchannel; cell ingrowth; mass exchange; bone tissue engineering poly(lactide-co-glycolide); hydroxyapatite; porous scaffold; microchannel; cell ingrowth; mass exchange; bone tissue engineering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhang, N.; Wang, Y.; Xu, W.; Hu, Y.; Ding, J. Poly(lactide-co-glycolide)/Hydroxyapatite Porous Scaffold with Microchannels for Bone Regeneration. Polymers 2016, 8, 218.

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