Next Article in Journal
Porphyrin Diacid-Polyelectrolyte Assemblies: Effective Photocatalysts in Solution
Next Article in Special Issue
Aerosol-Assisted Fast Formulating Uniform Pharmaceutical Polymer Microparticles with Variable Properties toward pH-Sensitive Controlled Drug Release
Previous Article in Journal
Simulation of Jetting in Injection Molding Using a Finite Volume Method
Previous Article in Special Issue
The Construction of an Aqueous Two-Phase System to Solve Weak-Aggregation of Gigaporous Poly(Styrene-Divinyl Benzene) Microspheres
Article Menu

Export Article

Open AccessArticle
Polymers 2016, 8(5), 181; doi:10.3390/polym8050181

Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy

1,2,3
,
1,2,* , 1,2
,
1,2
,
3,4,* , 3
and
3,4,*
1
State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China
2
Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, China
3
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
4
Center for Mesoscience, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Jung Kwon Oh and Shiyong Liu
Received: 29 January 2016 / Revised: 14 April 2016 / Accepted: 27 April 2016 / Published: 4 May 2016
(This article belongs to the Special Issue Selected Papers from ASEPFPM2015)
View Full-Text   |   Download PDF [2264 KB, uploaded 4 May 2016]   |  

Abstract

The inactivation of photosensitizers before they reach the targeted tissues can be an important factor, which limits the efficacy of photodynamic therapy (PDT). Here, we developed co-assembled nanohybrids of graphene oxide (GO) and albumin/photosensitizer that have a potential for protecting the photosensitizers from the environment and releasing them in targeted sites, allowing for an enhanced PDT. The nanohybrids were prepared by loading the pre-assembled nanoparticles of chlorin e6 (Ce6) and bovine serum albumin (BSA) on GO via non-covalent interactions. The protection to Ce6 is evident from the inhibited fluorescence and singlet oxygen generation activities of Ce6–BSA–GO nanohybrids. Importantly, compared to free Ce6 and Ce6 directly loaded by GO (Ce6–GO), Ce6–BSA–GO nanohybrids showed enhanced cellular uptake and in vitro release of Ce6, leading to an improved PDT efficiency. These results indicate that the smart photosensitizer delivery system constructed by co-assembly of GO and albumin is promising to improve the stability, biocompatibility, and efficiency of PDT. View Full-Text
Keywords: protein; graphene oxide; singlet oxygen generation; co-assembly; photodynamic therapy protein; graphene oxide; singlet oxygen generation; co-assembly; photodynamic therapy
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Xing, R.; Jiao, T.; Liu, Y.; Ma, K.; Zou, Q.; Ma, G.; Yan, X. Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy. Polymers 2016, 8, 181.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top