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Polymers 2016, 8(4), 91; doi:10.3390/polym8040091

Drug Delivery Systems Obtained from Silica Based Organic-Inorganic Hybrids

1
Faculdade de Ciências Farmacêuticas, UNESP—Univ Estadual Paulista, Araraquara-Jaú, Km 1, Araraquara 14800-903, Brazil
2
Departamento de Ciências Biológicas e da Saúde, Centro Universitário de Araraquara—UNIARA, Araraquara 14800-903, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Jianxun Ding
Received: 22 February 2016 / Revised: 8 March 2016 / Accepted: 10 March 2016 / Published: 24 March 2016
(This article belongs to the Special Issue Functional Polymers for Medical Applications)
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Abstract

This is a review of hybrid materials based on silica as an inorganic phase used as drug delivery systems (DDS). Silica based DDS have shown effectivity when compared with traditional delivery systems. They present advantages such as: (a) ability to maintain the therapeutic range with minor variations; (b) prevention of local and systemic toxic effects; (c) plasma concentrations increase of substances with a short half-life; and (d) reduction of the number of daily doses, which may increase patient adherence to the treatment. These advantages occur due to the physical, chemical and optical properties of these materials. Therefore, we discuss the properties and characteristics of them and we present some applications, using different approaches of DDS to ensure therapeutic effectiveness and side effects reduction such as implantable biomaterial, film-forming materials, stimuli-responsive systems and others. View Full-Text
Keywords: organic-inorganic materials; drug delivery systems; sol-gel process organic-inorganic materials; drug delivery systems; sol-gel process
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Oshiro Junior, J.A.; Paiva Abuçafy, M.; Berbel Manaia, E.; Lallo da Silva, B.; Chiari-Andréo, B.G.; Aparecida Chiavacci, L. Drug Delivery Systems Obtained from Silica Based Organic-Inorganic Hybrids. Polymers 2016, 8, 91.

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