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Polymers 2016, 8(4), 151; doi:10.3390/polym8040151

The in Vitro and in Vivo Degradation of Cross-Linked Poly(trimethylene carbonate)-Based Networks

1,2,3
,
1,2
,
1,2
and
3,*
1
Key Laboratory of Reproductive Health and Medical Genetics, National Health and Family Planning Commission, Shenyang 110031, China
2
Key Laboratory of Reproductive Health, Liaoning Research Institute of Family Planning, Shenyang 110031, China
3
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
*
Author to whom correspondence should be addressed.
Academic Editor: Jianxun Ding
Received: 18 March 2016 / Revised: 9 April 2016 / Accepted: 14 April 2016 / Published: 19 April 2016
(This article belongs to the Special Issue Functional Polymers for Medical Applications)
View Full-Text   |   Download PDF [10111 KB, uploaded 19 April 2016]   |  

Abstract

The degradation of the poly(trimethylene carbonate) (PTMC) and poly(trimethylene carbonate-co-ε-caprolactone) (P(TMC-co-CL)) networks cross-linked by 0.01 and 0.02 mol % 2,2′-bis(trimethylene carbonate-5-yl)-butylether (BTB) was carried out in the conditions of hydrolysis and enzymes in vitro and subcutaneous implantation in vivo. The results showed that the cross-linked PTMC networks exhibited much faster degradation in enzymatic conditions in vitro and in vivo versus in a hydrolysis case due to the catalyst effect of enzymes; the weight loss and physical properties of the degraded networks were dependent on the BTB amount. The morphology observation in lipase and in vivo illustrated that enzymes played an important role in the surface erosion of cross-linked PTMC. The hydrolytic degradation rate of the cross-linked P(TMC-co-CL) networks increased with increasing ε-caprolactone (CL) content in composition due to the preferential cleavage of ester bonds. Cross-linking is an effective strategy to lower the degradation rate and enhance the form-stability of PTMC-based materials. View Full-Text
Keywords: cross-linked networks; poly(trimethylene carbonate); in vitro degradation; in vivo degradation; form-stability cross-linked networks; poly(trimethylene carbonate); in vitro degradation; in vivo degradation; form-stability
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Yang, L.; Li, J.; Li, M.; Gu, Z. The in Vitro and in Vivo Degradation of Cross-Linked Poly(trimethylene carbonate)-Based Networks. Polymers 2016, 8, 151.

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