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Polymers 2016, 8(4), 141; doi:10.3390/polym8040141

pH-Triggered Sheddable Shielding System for Polycationic Gene Carriers

1
School of Chemistry and Chemical Engineering, Lingnan Normal University, 29 Cunjin Road, Zhanjiang 524048, China
2
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Science, 5625 Renmin Street, Changchun 130022, China
3
Development Center for New Materials Engineering & Technology in Universities of Guangdong, Zhanjiang 524048, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Carsten Werner and Jianxun Ding
Received: 29 February 2016 / Revised: 28 March 2016 / Accepted: 5 April 2016 / Published: 14 April 2016
(This article belongs to the Special Issue Functional Polymers for Medical Applications)
View Full-Text   |   Download PDF [3322 KB, uploaded 14 April 2016]   |  

Abstract

For improving the therapeutic efficiency of tumors and decreasing undesirable side effects, ternary complexes were developed by coating pH-sensitive PEG-b-PLL-g-succinylsulfathiazole (hereafter abbreviated as PPSD) with DNA/PEI polyplexes via electrostatic interaction. PPSD can efficiently shield the surface charge of DNA/PEI. The gene transfection efficiency of ternary complexes was lower than that of DNA/PEI at pH 7.4; however, it recovered to the same level as that of DNA/PEI at pH 6.0, attributed to the pH-triggered release of DNA/PEI from ternary complexes. Cell uptake results also exhibited the same trend as transfection at different pH values. The suitable ability for pH-triggered shielding/deshielding estimated that PPSD demonstrates potential as a shielding system for use in in vivo gene delivery. View Full-Text
Keywords: gene delivery; shielding system; pH-sensitive gene delivery; shielding system; pH-sensitive
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Xia, J.; Tian, H.; Chen, J.; Lin, L.; Guo, Z.; Han, B.; Yang, H.; Feng, Z. pH-Triggered Sheddable Shielding System for Polycationic Gene Carriers. Polymers 2016, 8, 141.

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