pH-Triggered Sheddable Shielding System for Polycationic Gene Carriers
AbstractFor improving the therapeutic efficiency of tumors and decreasing undesirable side effects, ternary complexes were developed by coating pH-sensitive PEG-b-PLL-g-succinylsulfathiazole (hereafter abbreviated as PPSD) with DNA/PEI polyplexes via electrostatic interaction. PPSD can efficiently shield the surface charge of DNA/PEI. The gene transfection efficiency of ternary complexes was lower than that of DNA/PEI at pH 7.4; however, it recovered to the same level as that of DNA/PEI at pH 6.0, attributed to the pH-triggered release of DNA/PEI from ternary complexes. Cell uptake results also exhibited the same trend as transfection at different pH values. The suitable ability for pH-triggered shielding/deshielding estimated that PPSD demonstrates potential as a shielding system for use in in vivo gene delivery. View Full-Text
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Xia, J.; Tian, H.; Chen, J.; Lin, L.; Guo, Z.; Han, B.; Yang, H.; Feng, Z. pH-Triggered Sheddable Shielding System for Polycationic Gene Carriers. Polymers 2016, 8, 141.
Xia J, Tian H, Chen J, Lin L, Guo Z, Han B, Yang H, Feng Z. pH-Triggered Sheddable Shielding System for Polycationic Gene Carriers. Polymers. 2016; 8(4):141.Chicago/Turabian Style
Xia, Jialiang; Tian, Huayu; Chen, Jie; Lin, Lin; Guo, Zhaopei; Han, Bing; Yang, Hongyan; Feng, Zongcai. 2016. "pH-Triggered Sheddable Shielding System for Polycationic Gene Carriers." Polymers 8, no. 4: 141.
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