Next Article in Journal
New Concept of Polymethyl Methacrylate (PMMA) and Polyethylene Terephthalate (PET) Surface Coating by Chitosan
Next Article in Special Issue
Structural Properties and Antifungal Activity against Candida albicans Biofilm of Different Composite Layers Based on Ag/Zn Doped Hydroxyapatite-Polydimethylsiloxanes
Previous Article in Journal
On the Effect of Nanoparticle Surface Chemistry on the Electrical Characteristics of Epoxy-Based Nanocomposites
Previous Article in Special Issue
Biodegradable Polymer Membranes Applied in Guided Bone/Tissue Regeneration: A Review
Article Menu

Export Article

Open AccessArticle
Polymers 2016, 8(4), 130; doi:10.3390/polym8040130

A Thixotropic Polyglycerol Sebacate-Based Supramolecular Hydrogel as an Injectable Drug Delivery Matrix

1
Institute of Materials Research and Engineering (IMRE), A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634, Singapore
2
College of Chemistry, Jilin University, Changchun 130012, China
3
Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117575, Singapore
4
Department of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, Singapore 117583, Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Jianxun Ding
Received: 27 February 2016 / Revised: 22 March 2016 / Accepted: 25 March 2016 / Published: 7 April 2016
(This article belongs to the Special Issue Functional Polymers for Medical Applications)
View Full-Text   |   Download PDF [7320 KB, uploaded 7 April 2016]   |  

Abstract

We have developed a “self-healing” polyglycerol sebacate—polyethylene glycol methyl ether methacrylate (PGS-PEGMEMA)/α-Cyclodextrin (αCD) hydrogel which could be sheared into a liquid during injection and has the potential to quickly “heal” itself back into gel post-injection. This hydrogel was shown to be biocompatible and biodegradable and therefore appropriate for use in vivo. Furthermore, the storage and loss moduli of the hydrogels could be tuned (by varying the concentration of αCD) between a fraction of a kPa to a few 100 kPa, a range that coincides with the moduli of cells and human soft tissues. This property would allow for this hydrogel to be used in vivo with maximal mechanical compatibility with human soft tissues. In vitro experiments showed that the hydrogel demonstrated a linear mass erosion profile and a biphasic drug (doxorubicin) release profile: Phase I was primarily driven by diffusion and Phase II was driven by hydrogel erosion. The diffusion mechanism was modeled with the First Order equation and the erosion mechanism with the Hopfenberg equation. This established fitting model could be used to predict releases with other drugs and estimate the composition of the hydrogel required to achieve a desired release rate. View Full-Text
Keywords: polyglycerol sebacate; shear-thinning; self-healing; injectable hydrogel; supramolecular polyglycerol sebacate; shear-thinning; self-healing; injectable hydrogel; supramolecular
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ye, H.; Owh, C.; Jiang, S.; Ng, C.Z.Q.; Wirawan, D.; Loh, X.J. A Thixotropic Polyglycerol Sebacate-Based Supramolecular Hydrogel as an Injectable Drug Delivery Matrix. Polymers 2016, 8, 130.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top