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Polymers 2016, 8(2), 49; doi:10.3390/polym8020049

Development of Poly(ɛ-caprolactone) Scaffold Loaded with Simvastatin and Beta-Cyclodextrin Modified Hydroxyapatite Inclusion Complex for Bone Tissue Engineering

1
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212, USA
2
Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37235, USA
3
Department of Maxillofacial Biomedical Engineering, Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Korea
4
Department of Nature-Inspired Nanoconvergence Systems, Korea Institute of Machinery and Materials, 156 Gajeongbuk-ro, Yuseong-gu, Daejeon 304-343, Korea
5
Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN 37235, USA
6
Department of Biomedical Engineering, College of Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Korea
7
School of Chemical Engineering & SKKU Advanced Institute of Nanotechnology, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Korea
8
Department of Oral and Maxillofacial Radiology, College of Medicine, School of Dentistry, Kyung Hee University, Seoul 130-701, Korea
9
Severance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul 120-752, Korea
*
Author to whom correspondence should be addressed.
Received: 1 December 2015 / Revised: 26 January 2016 / Accepted: 5 February 2016 / Published: 9 February 2016
(This article belongs to the Special Issue Polymers Applied in Tissue Engineering)
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Abstract

In this study, we developed poly(ɛ-caprolactone) (PCL) 3D scaffolds using a solid free form fabrication (SFF) technique. β-cyclodextrin (βCD) was grafted to hydroxyapatite (HAp) and this βCD grafted HAp was coated onto the PCL scaffold surface, followed by drug loading through an inclusion complex interaction between the βCD and adamantane (AD) or between βCD and simvastatin (SIM). The scaffold structure was characterized by scanning electron microscopy (SEM). The release profile of simvastatin in the β-CD grafted HAp was also evaluated. Osteogenic differentiation of adipose-derived stromal cells (ADSCs) was examined using an alkaline phosphatase activity (ALP) assay. The results suggest that drug loaded PCL-HAp 3-D scaffolds enhances osteogenic differentiation of ADSCs. View Full-Text
Keywords: β-cyclodextrin; hydroxyapatite; poly(ɛ-caprolactone) 3-D scaffolds; simvastatin; bone regeneration β-cyclodextrin; hydroxyapatite; poly(ɛ-caprolactone) 3-D scaffolds; simvastatin; bone regeneration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, J.B.; Kim, J.E.; Bae, M.S.; Park, S.A.; Balikov, D.A.; Sung, H.-J.; Jeon, H.B.; Park, H.K.; Um, S.H.; Lee, K.S.; Kwon, I.K. Development of Poly(ɛ-caprolactone) Scaffold Loaded with Simvastatin and Beta-Cyclodextrin Modified Hydroxyapatite Inclusion Complex for Bone Tissue Engineering. Polymers 2016, 8, 49.

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