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Polymers 2016, 8(2), 30; doi:10.3390/polym8020030

Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery

1
Division of Bioengineering, Incheon National University, Incheon 406-772, Korea
2
Department of Preventive Dental Sciences, College of Dentistry, Jazan University, P.O Box 114, Jazan 45142, Saudi Arabia
3
Marine Bioprocess Research Center and Department of Marine-bio Convergence Science, Pukyong National University, Busan 608-737, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Jianxun Ding
Received: 3 November 2015 / Revised: 4 January 2016 / Accepted: 11 January 2016 / Published: 26 January 2016
View Full-Text   |   Download PDF [4090 KB, uploaded 26 January 2016]   |  

Abstract

In recent years, there have been major advances and increasing amounts of research on the utilization of natural polymeric materials as drug delivery vehicles due to their biocompatibility and biodegradability. Seaweed polysaccharides are abundant resources and have been extensively studied for several biological, biomedical, and functional food applications. The exploration of seaweed polysaccharides for drug delivery applications is still in its infancy. Alginate, carrageenan, fucoidan, ulvan, and laminarin are polysaccharides commonly isolated from seaweed. These natural polymers can be converted into nanoparticles (NPs) by different types of methods, such as ionic gelation, emulsion, and polyelectrolyte complexing. Ionic gelation and polyelectrolyte complexing are commonly employed by adding cationic molecules to these anionic polymers to produce NPs of a desired shape, size, and charge. In the present review, we have discussed the preparation of seaweed polysaccharide-based NPs using different types of methods as well as their usage as carriers for the delivery of various therapeutic molecules (e.g., proteins, peptides, anti-cancer drugs, and antibiotics). Seaweed polysaccharide-based NPs exhibit suitable particle size, high drug encapsulation, and sustained drug release with high biocompatibility, thereby demonstrating their high potential for safe and efficient drug delivery. View Full-Text
Keywords: alginate; carrageenan; fucoidan; drug delivery alginate; carrageenan; fucoidan; drug delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Venkatesan, J.; Anil, S.; Kim, S.-K.; Shim, M.S. Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery. Polymers 2016, 8, 30.

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