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Polymers 2016, 8(1), 23; doi:10.3390/polym8010023

Engineered Polymeric Hydrogels for 3D Tissue Models

Division of Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Korea
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Academic Editor: Esmaiel Jabbari
Received: 30 November 2015 / Revised: 4 January 2016 / Accepted: 15 January 2016 / Published: 20 January 2016
(This article belongs to the Special Issue Polymers Applied in Tissue Engineering)
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Abstract

Polymeric biomaterials are widely used in a wide range of biomedical applications due to their unique properties, such as biocompatibility, multi-tunability and easy fabrication. Specifically, polymeric hydrogel materials are extensively utilized as therapeutic implants and therapeutic vehicles for tissue regeneration and drug delivery systems. Recently, hydrogels have been developed as artificial cellular microenvironments because of the structural and physiological similarity to native extracellular matrices. With recent advances in hydrogel materials, many researchers are creating three-dimensional tissue models using engineered hydrogels and various cell sources, which is a promising platform for tissue regeneration, drug discovery, alternatives to animal models and the study of basic cell biology. In this review, we discuss how polymeric hydrogels are used to create engineered tissue constructs. Specifically, we focus on emerging technologies to generate advanced tissue models that precisely recapitulate complex native tissues in vivo. View Full-Text
Keywords: polymeric hydrogels; engineered tissue models; artificial extracellular matrices; tissue engineering; drug screening; basic cell biology polymeric hydrogels; engineered tissue models; artificial extracellular matrices; tissue engineering; drug screening; basic cell biology
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Park, S.; Park, K.M. Engineered Polymeric Hydrogels for 3D Tissue Models. Polymers 2016, 8, 23.

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