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Polymers 2015, 7(3), 484-503; doi:10.3390/polym7030484

Effects of RAFT Agent on the Selective Approach of Molecularly Imprinted Polymers

1
Department of Chemistry, Faculty of Science, University of Malaya, Lembah Pantai, 50603 Kuala Lumpur, Malaysia
2
Department of Science and Mathematics, Faculty of Science, Technology and Human Development, University of Tun Hussein Onn Malaysia, Parit Raja, 86400 Johor, Malaysia
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Philipp Vana
Received: 12 July 2014 / Revised: 16 February 2015 / Accepted: 2 March 2015 / Published: 6 March 2015
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Abstract

Two types of reversible addition-fragmentation chain transfer molecularly imprinted polymers (RAFT-MIPs) were synthesized using different monomers, which were methacrylic acid functionalized β-cyclodextrin (MAA-β-CD) and 2-hydroxyethyl methacrylate functionalized β-cyclodextrin (HEMA-β-CD), via reversible addition-fragmentation chain transfer (RAFT) polymerization, and were represented as RAFT-MIP(MAA-β-CD) and RAFT-MIP(HEMA-β-CD), respectively. Both RAFT-MIPs were systematically characterized using Fourier Transform Infrared Spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FESEM), Brunauer-Emmett-Teller (BET), and rebinding experimental study. The results were compared with MIPs synthesized via the traditional radical polymerization (TRP) process, and were represented as MIP(MAA-β-CD) and MIP(HEMA-β-CD). Morphology results show that RAFT-MIP(MAA-β-CD) has a slightly spherical feature with a sponge-like form, while RAFT-MIP(HEMA-β-CD) has a compact surface. BET results show that the surface area of RAFT-MIP(MAA-β-CD) is higher than MIP(MAA-β-CD), while the RAFT-MIP(HEMA-β-CD) surface area is lower than that of MIP(HEMA-β-CD). Rebinding experiments indicate that the RAFT agent increased the binding capacity of RAFT-MIP(MAA-β-CD), but not of RAFT-MIP(HEMA-β-CD), which proves that a RAFT agent does not always improve the recognition affinity and selective adsorption of MIPs. The usability of a RAFT agent depends on the monomer used to generate potential MIPs. View Full-Text
Keywords: molecularly imprinted polymer; methacrylic acid functionalized β-cyclodextrin; 2-hydroxyethyl methacrylate functionalized β-cyclodextrin; RAFT agent molecularly imprinted polymer; methacrylic acid functionalized β-cyclodextrin; 2-hydroxyethyl methacrylate functionalized β-cyclodextrin; RAFT agent
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Asman, S.; Mohamad, S.; Sarih, N.M. Effects of RAFT Agent on the Selective Approach of Molecularly Imprinted Polymers. Polymers 2015, 7, 484-503.

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