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Polymers 2015, 7(2), 281-297; doi:10.3390/polym7020281

Active Peptide-Conjugated Chitosan Matrices as an Artificial Basement Membrane

Department of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
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Academic Editor: Kell Mortensen
Received: 27 November 2014 / Accepted: 3 February 2015 / Published: 11 February 2015
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Abstract

The basement membrane, a thin extracellular matrix, plays a critical role in tissue development and repair. Laminins are the major component of basement membrane and have diverse biological activities. We have identified various cell-adhesive peptides from laminins and their specific cell surface receptors. Polysaccharides, including chitosan, have been used as scaffolds, which regulate cellular functions for tissue engineering. We have developed laminin-derived active peptide-chitosan matrices as functional scaffolds. The biological activity of the peptides was enhanced when the peptides were conjugated to a chitosan matrix, suggesting that the peptide-chitosan matrix approach has an advantage for an active biomaterial. Further, the laminin peptide-chitosan matrices have the potential to mimic the basement membrane and are useful for tissue engineering as an artificial basement membrane. View Full-Text
Keywords: basement membrane; laminin; peptides; polysaccharide basement membrane; laminin; peptides; polysaccharide
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hozumi, K.; Kumai, J.; Yamada, Y.; Nomizu, M. Active Peptide-Conjugated Chitosan Matrices as an Artificial Basement Membrane. Polymers 2015, 7, 281-297.

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