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Polymers 2015, 7(11), 2304-2315; doi:10.3390/polym7111515

Leads from Physical, Chemical, and Thermal Characterization on Cytotoxic Effects of Xylan-Based Microparticles

1
Programa de Pós-graduação em Ciências Farmacêuticas (PPgCF), Universidade Federal do Rio Grande do Norte (UFRN), Natal/RN 59010-180, Brazil
2
Programa de Pós-graduação em Ciências da Saúde (PPgCSa), Universidade Federal Rio Grande do Norte (UFRN), Natal/RN 59010-180, Brazil
3
Laboratório de Síntese e Vetorização de Moléculas, Centro de Ciências Biológicas e Sociais Aplicadas, Universidade Estadual da Paraíba (UEPB), João Pessoa/PB 58070-450, Brazil
4
Centro de Educação e Saúde-Campus Avançado de Cuité, Universidade Federal de Campina Grande (UFCG), Cuité/PB 59175-000, Brazil
5
Departamento de Física, Campus Ministro Petrônio Portella, Universidade Federal do Piauí, Teresina/PI 64049-550, Brazil
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Departamento de Biologia Celular e Genética, Universidade Federal do Rio Grande do Norte (UFRN), Natal/RN 59010-180, Brazil
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Departamento de Física, Universidade Federal do Ceará (UFC), Fortaleza/CE 60020-181, Brazil
8
Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas, Universidade do Estado de São Paulo (UNESP), Araraquara/SP 14801-902, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Francoise Winnik
Received: 11 June 2015 / Revised: 26 July 2015 / Accepted: 3 August 2015 / Published: 16 November 2015
View Full-Text   |   Download PDF [3055 KB, uploaded 16 November 2015]   |  

Abstract

Interfacial cross-linking (ICL) has been considered a feasible technique to produce polysaccharide-based microparticles (PbMs), even though only a few studies have been concerned with their biocompatibility. In this work, PbMs were prepared by the ICL method and characterized in regard to their in vitro biocompatibility, chemical linkages, and physical and thermal properties. First, the cell viability assay revealed that PbMs toxicity was concentration-dependent. Then, it was observed that the toxicity may be related to the way in which the binding occurred, and not exclusively to the stoichiometry between the polymer and the cross-linking agent. Moreover, the PbMs biosafety was predicted by the use of physicochemical procedures, which were able to identify unbound cross-linking agent residues and also to reveal the improvement of their thermal stability. Accordingly, this work suggests a step-by-step physicochemical procedure able to predict potential toxicity from micro-structured devices produced by polysaccharides. Likewise, the use of PbMs as a drug carrier should be cautiously considered. View Full-Text
Keywords: biocompatibility; interfacial cross-linking; polysaccharide; terephthaloyl chloride; microparticles biocompatibility; interfacial cross-linking; polysaccharide; terephthaloyl chloride; microparticles
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Marcelino, H.R.; da Silva, A.E.; Gomes, M.C.S.; Oliveira, E.E.; Nagashima-Junior, T.; Pinheiro, G.S.; da Silva, A.E.; Timoteo, A.R.S.; Agnez-Lima, L.F.; Ayala, A.P.; Oliveira, A.G.; do Egito, E.S.T. Leads from Physical, Chemical, and Thermal Characterization on Cytotoxic Effects of Xylan-Based Microparticles. Polymers 2015, 7, 2304-2315.

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