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Polymers 2014, 6(5), 1502-1527; doi:10.3390/polym6051502
Review

Polyelectrolyte Multilayers: Towards Single Cell Studies

1,* , 2
 and
3
1 Fraunhofer Institute for Biomedical Engineering, Am Mühlenberg 13, Potsdam-Golm 14476, Germany 2 Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 124, Berlin 10623, Germany 3 Department of Interfaces, Max-Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, Potsdam-Golm 14476, Germany
* Author to whom correspondence should be addressed.
Received: 3 March 2014 / Revised: 30 April 2014 / Accepted: 3 May 2014 / Published: 20 May 2014
(This article belongs to the Special Issue Biomimetic Polymers)
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Abstract

Single cell analysis (SCA) is nowadays recognized as one of the key tools for diagnostics and fundamental cell biology studies. The Layer-by-layer (LbL) polyelectrolyte assembly is a rather new but powerful technique to produce multilayers. It allows to model the extracellular matrix in terms of its chemical and physical properties. Utilization of the multilayers for SCA may open new avenues in SCA because of the triple role of the multilayer film: (i) high capacity for various biomolecules; (ii) natural mimics of signal molecule diffusion to a cell and (iii) cell patterning opportunities. Besides, light-triggered release from multilayer films offers a way to deliver biomolecules with high spatio-temporal resolution. Here we review recent works showing strong potential to use multilayers for SCA and address accordingly the following issues: biomolecule loading, cell patterning, and light-triggered release.
Keywords: layer-by-layer; thin films; capsule; release; cell patterning; multilayer layer-by-layer; thin films; capsule; release; cell patterning; multilayer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Volodkin, D.; von Klitzing, R.; Moehwald, H. Polyelectrolyte Multilayers: Towards Single Cell Studies. Polymers 2014, 6, 1502-1527.

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