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Polymers 2014, 6(3), 846-859; doi:10.3390/polym6030846
Article

Thermo-Responsive and Biocompatible Diblock Copolymers Prepared via Reversible Addition-Fragmentation Chain Transfer (RAFT) Radical Polymerization

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Received: 19 February 2014; in revised form: 6 March 2014 / Accepted: 11 March 2014 / Published: 17 March 2014
(This article belongs to the Special Issue Controlled/Living Radical Polymerization)
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Abstract: Poly(2-(methacryloyloxy)ethyl phosphorylcholine)-b-poly(N,N-diethyl acrylamide) (PMPCm-PDEAn) was synthesized via reversible addition-fragmentation chain transfer (RAFT) controlled radical polymerization. Below, the critical aggregation temperature (CAT) the diblock copolymer dissolved in water as a unimer with a hydrodynamic radius (Rh) of ca. 5 nm. Above the CAT the diblock copolymers formed polymer micelles composed of a PDEA core and biocompatible PMPC shells, due to hydrophobic self-aggregation of the thermo-responsive PDEA block. A fluorescence probe study showed that small hydrophobic small guest molecules could be incorporated into the core of the polymer micelle above the CAT. The incorporated guest molecules were released from the core into the bulk aqueous phase when the temperature decreased to values below the CAT because of micelle dissociation.
Keywords: block copolymers; micelles; RAFT polymerization; water-soluble polymers; critical aggregation temperature block copolymers; micelles; RAFT polymerization; water-soluble polymers; critical aggregation temperature
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Fukuda, K.; Enomoto, R.; Ishihara, K.; Morishima, Y.; Yusa, S.-I. Thermo-Responsive and Biocompatible Diblock Copolymers Prepared via Reversible Addition-Fragmentation Chain Transfer (RAFT) Radical Polymerization. Polymers 2014, 6, 846-859.

AMA Style

Fukuda K, Enomoto R, Ishihara K, Morishima Y, Yusa S-I. Thermo-Responsive and Biocompatible Diblock Copolymers Prepared via Reversible Addition-Fragmentation Chain Transfer (RAFT) Radical Polymerization. Polymers. 2014; 6(3):846-859.

Chicago/Turabian Style

Fukuda, Kenichi; Enomoto, Ryusuke; Ishihara, Kazuhiko; Morishima, Yotaro; Yusa, Shin-ichi. 2014. "Thermo-Responsive and Biocompatible Diblock Copolymers Prepared via Reversible Addition-Fragmentation Chain Transfer (RAFT) Radical Polymerization." Polymers 6, no. 3: 846-859.


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