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Polymers 2014, 6(10), 2670-2683; doi:10.3390/polym6102670

Thermo-Responsive Injectable MPEG-Polyester Diblock Copolymers for Sustained Drug Release

1
Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Korea
2
Department of BIN Fusion Technology, Chonbuk National University, Jeonju 561-756, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 16 September 2014 / Revised: 7 October 2014 / Accepted: 17 October 2014 / Published: 23 October 2014
(This article belongs to the Special Issue Polymer Colloids)
View Full-Text   |   Download PDF [1731 KB, uploaded 23 October 2014]   |  

Abstract

Thermo-responsive diblock copolymers composed of hydrophilic methoxy poly(ethylene glycol) (MPEG) and hydrophobic biodegradable polyesters were prepared for application as injectable drug delivery systems, because they show a thermo-responsive sol-to-gel transition, especially around body temperature, when dispersed in aqueous solutions. The thermogelling hydrogels formed by hydrophobic aggregation could be varied by changing the components of the hydrophobic polyester part. For the polyester block in the present study, 95 mol% of ε-caprolactone (CL) was used for the main polyester chain and 5 mol% of p-dioxanone (DO) was copolymerized randomly by the MPEG initiator in the presence of HCl as the catalyst. By adding a small portion of DO into the poly ε-caprolactone (PCL) chains, the temperature range of gelation, the intensity of viscosity and the drug release behavior were changed. The MPEG-b-poly(ε-caprolactone-ran-p-dioxanone) (MPEG-b-PCDO) hydrogel showed the enhanced drug release in vitro and in vivo compared to MPEG-b-PCL hydrogel. Therefore, MPEG-polyester hydrogels may serve as minimally invasive and therapeutic, injectable hydrogel systems with adjustable temperature-responsive and biodegradable windows, as well as sustained release of drugs over a certain time period. View Full-Text
Keywords: thermo-responsive hydrogels; biodegradable polyesters; block copolymers; sustained release thermo-responsive hydrogels; biodegradable polyesters; block copolymers; sustained release
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hyun, H.; Park, S.H.; Kwon, D.Y.; Khang, G.; Lee, H.B.; Kim, M.S. Thermo-Responsive Injectable MPEG-Polyester Diblock Copolymers for Sustained Drug Release. Polymers 2014, 6, 2670-2683.

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