Polymers 2012, 4(3), 1349-1398; doi:10.3390/polym4031349

Polymer-Based Microfluidic Devices for Pharmacy, Biology and Tissue Engineering

1,2email, 1,2,3email and 1,2,* email
Received: 2 March 2012; in revised form: 4 May 2012 / Accepted: 18 June 2012 / Published: 3 July 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: This paper reviews microfluidic technologies with emphasis on applications in the fields of pharmacy, biology, and tissue engineering. Design and fabrication of microfluidic systems are discussed with respect to specific biological concerns, such as biocompatibility and cell viability. Recent applications and developments on genetic analysis, cell culture, cell manipulation, biosensors, pathogen detection systems, diagnostic devices, high-throughput screening and biomaterial synthesis for tissue engineering are presented. The pros and cons of materials like polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), polystyrene (PS), polycarbonate (PC), cyclic olefin copolymer (COC), glass, and silicon are discussed in terms of biocompatibility and fabrication aspects. Microfluidic devices are widely used in life sciences. Here, commercialization and research trends of microfluidics as new, easy to use, and cost-effective measurement tools at the cell/tissue level are critically reviewed.
Keywords: microfluidics; tissue engineering; biomedical engineering; polymers; biocompatibility; cell sorting; cell analysis; cell biology
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MDPI and ACS Style

Alrifaiy, A.; Lindahl, O.A.; Ramser, K. Polymer-Based Microfluidic Devices for Pharmacy, Biology and Tissue Engineering. Polymers 2012, 4, 1349-1398.

AMA Style

Alrifaiy A, Lindahl OA, Ramser K. Polymer-Based Microfluidic Devices for Pharmacy, Biology and Tissue Engineering. Polymers. 2012; 4(3):1349-1398.

Chicago/Turabian Style

Alrifaiy, Ahmed; Lindahl, Olof A.; Ramser, Kerstin. 2012. "Polymer-Based Microfluidic Devices for Pharmacy, Biology and Tissue Engineering." Polymers 4, no. 3: 1349-1398.

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