Polymers 2011, 3(4), 1776-1793; doi:10.3390/polym3041776
Review

Regeneration Approaches for Dental Pulp and Periapical Tissues with Growth Factors, Biomaterials, and Laser Irradiation

1 Division of Pulp Biology, Operative Dentistry, and Endodontics, Department of Cariology and Periodontology, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803 8580, Japan 2 Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803-8580, Japan 3 Division of Comprehensive Dentistry, Department of Clinical Communication and Practice, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803-8580, Japan 4 Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan 5 Division of Molecular Signaling and Biochemistry, Department of Biosciences, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803-8580, Japan
* Author to whom correspondence should be addressed.
Received: 4 August 2011; in revised form: 26 September 2011 / Accepted: 11 October 2011 / Published: 12 October 2011
(This article belongs to the Special Issue Polymers for Oro-Dental and Cranio- Maxillo-Facial Applications)
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Abstract: In current dental practice, restorative and endodontic procedures have been developed in an attempt to preserve the vitality of dental pulp after exposure to external stimuli such as caries infection. When damage to dental pulp is reversible, pulp wound healing can proceed, whereas irreversible damage induces pathological changes in dental pulp, eventually requiring its removal. Furthermore, dentists sometimes extract non-vital teeth because of severe caries progression, critical size of periapical lesion, and tooth fracture. To overcome the limitations of presently available therapies, it is important to develop regeneration therapy for dental pulp and periapical tissues. In this review, we focus on the regeneration of dental pulp and periapical tissues by application of exogenous growth factors and scaffolds, as well as low-intensity laser irradiation as an auxiliary therapy for regeneration therapy.
Keywords: dental pulp regeneration; regeneration of bone defects; FGF2; gelatin hydrogels; laser irradiation

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MDPI and ACS Style

Kitamura, C.; Nishihara, T.; Terashita, M.; Tabata, Y.; Jimi, E.; Washio, A.; Hirata, S. Regeneration Approaches for Dental Pulp and Periapical Tissues with Growth Factors, Biomaterials, and Laser Irradiation. Polymers 2011, 3, 1776-1793.

AMA Style

Kitamura C, Nishihara T, Terashita M, Tabata Y, Jimi E, Washio A, Hirata S. Regeneration Approaches for Dental Pulp and Periapical Tissues with Growth Factors, Biomaterials, and Laser Irradiation. Polymers. 2011; 3(4):1776-1793.

Chicago/Turabian Style

Kitamura, Chiaki; Nishihara, Tatsuji; Terashita, Masamichi; Tabata, Yasuhiko; Jimi, Eijiro; Washio, Ayako; Hirata, Shizu. 2011. "Regeneration Approaches for Dental Pulp and Periapical Tissues with Growth Factors, Biomaterials, and Laser Irradiation." Polymers 3, no. 4: 1776-1793.

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