Polymers 2011, 3(1), 314-329; doi:10.3390/polym3010314
Poly(alkyl methacrylate) Tooth Coatings for Dental Care: Evaluation of the Demineralisation-Protection Benefit Using a Time-Resolved In Vitro Method
Birthe V. Nielsen 1,2, Thomas G. Nevell 1, Eugen Barbu 1, James R. Smith 1
, Gareth D. Rees 3 and John Tsibouklis 1,*
, Gareth D. Rees 3 and John Tsibouklis 1,*
1
School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, Hampshire, PO1 2DT, UK
2
School of Science, University of Greenwich, Chatham Maritime, Kent, ME1 4TB, UK
3
GlaxoSmithKline R&D, St George’s Avenue, Weybridge, Surrey, KT13 0DE, UK
*
Author to whom correspondence should be addressed.
Received: 8 December 2010 / Revised: 24 December 2010 / Accepted: 17 January 2011 / Published: 19 January 2011
(This article belongs to the Special Issue Biofunctional Polymers for Medical Applications)
Abstract
An in vitro method for the time-resolved quantification of acid-mediated tooth demineralisation has been developed and evaluated against putative non-permanent protective formulations based on a series of poly(alkyl methacrylate)s. Using a thermostatted carousel, dentally relevant substrates consisting of hydroxyapatite discs or sections of bovine teeth have been exposed to aqueous citric acid under controlled conditions, before and after being treated with the polymeric coatings. The dissolution of phosphate was monitored by the determination of 31P by Inductively Coupled Plasma—Mass Spectrometry and by the spectrophotometric phosphovanadomolybdate method. Dose-response plots constructed for both groups of treated substrates have revealed that the coatings significantly reduce erosion rates but are less effective at inhibiting tooth demineralisation than the standard fluoride treatment. The approach has enabled an evaluation of the erosion-protection efficiency of each coating. View Full-TextKeywords:
tooth demineralisation; ICP-MS; phosphovanadomolybdate; poly(alkyl methacrylate); erosion-protection coating
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MDPI and ACS Style
Nielsen, B.V.; Nevell, T.G.; Barbu, E.; Smith, J.R.; Rees, G.D.; Tsibouklis, J. Poly(alkyl methacrylate) Tooth Coatings for Dental Care: Evaluation of the Demineralisation-Protection Benefit Using a Time-Resolved In Vitro Method. Polymers 2011, 3, 314-329.
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