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Polymers 2011, 3(1), 193-221; doi:10.3390/polym3010193
Review

Recent Advances in Ocular Drug Delivery Systems

*  and
Research and Development Center, Santen Pharmaceutical Co., Ltd., 8916-16 Takayama-cho, Ikoma-shi, Nara 630-0101, Japan
* Author to whom correspondence should be addressed.
Received: 2 November 2010 / Revised: 9 December 2010 / Accepted: 31 December 2010 / Published: 6 January 2011
(This article belongs to the Special Issue Biofunctional Polymers for Medical Applications)
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Abstract

Transport of drugs applied by traditional dosage forms is restricted to the eye, and therapeutic drug concentrations in the target tissues are not maintained for a long duration since the eyes are protected by a unique anatomy and physiology. For the treatment of the anterior segment of the eye, various droppable products to prolong the retention time on the ocular surface have been introduced in the market. On the other hand, direct intravitreal implants, using biodegradable or non-biodegradable polymer technology, have been widely investigated for the treatment of chronic vitreoretinal diseases. There is urgent need to develop ocular drug delivery systems which provide controlled release for the treatment of chronic diseases, and increase patient’s and doctor’s convenience to reduce the dosing frequency and invasive treatment. In this article, progress of ocular drug delivery systems under clinical trials and in late experimental stage is reviewed.
Keywords: eye; drug delivery systems; ocular barriers; intravitreal implant eye; drug delivery systems; ocular barriers; intravitreal implant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kuno, N.; Fujii, S. Recent Advances in Ocular Drug Delivery Systems. Polymers 2011, 3, 193-221.

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