Polymers 2011, 3(1), 193-221; doi:10.3390/polym3010193
Review

Recent Advances in Ocular Drug Delivery Systems

* email and email
Received: 2 November 2010; in revised form: 9 December 2010 / Accepted: 31 December 2010 / Published: 6 January 2011
(This article belongs to the Special Issue Biofunctional Polymers for Medical Applications)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Transport of drugs applied by traditional dosage forms is restricted to the eye, and therapeutic drug concentrations in the target tissues are not maintained for a long duration since the eyes are protected by a unique anatomy and physiology. For the treatment of the anterior segment of the eye, various droppable products to prolong the retention time on the ocular surface have been introduced in the market. On the other hand, direct intravitreal implants, using biodegradable or non-biodegradable polymer technology, have been widely investigated for the treatment of chronic vitreoretinal diseases. There is urgent need to develop ocular drug delivery systems which provide controlled release for the treatment of chronic diseases, and increase patient’s and doctor’s convenience to reduce the dosing frequency and invasive treatment. In this article, progress of ocular drug delivery systems under clinical trials and in late experimental stage is reviewed.
Keywords: eye; drug delivery systems; ocular barriers; intravitreal implant
PDF Full-text Download PDF Full-Text [749 KB, uploaded 6 January 2011 14:23 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Kuno, N.; Fujii, S. Recent Advances in Ocular Drug Delivery Systems. Polymers 2011, 3, 193-221.

AMA Style

Kuno N, Fujii S. Recent Advances in Ocular Drug Delivery Systems. Polymers. 2011; 3(1):193-221.

Chicago/Turabian Style

Kuno, Noriyuki; Fujii, Shinobu. 2011. "Recent Advances in Ocular Drug Delivery Systems." Polymers 3, no. 1: 193-221.

Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert