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Bio-Inspired/-Functional Colloidal Core-Shell Polymeric-Based NanoSystems: Technology Promise in Tissue Engineering, Bioimaging and NanoMedicine
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 South 2000 East, Salt Lake City, UT, 84112-5820, USA
Department of Bioengineering & Regenerative Medicine, Utah-Inha DDS & Advanced Therapeutics Research Center, B-404 Meet-You-All Tower, Songdo TechnoPark 7-50, Songdo-Dong, Yeonsu-Gu, Incheon, 406-840, Republic of South Korea
Received: 16 August 2010; in revised form: 13 September 2010 / Accepted: 16 September 2010 / Published: 20 September 2010
Abstract: Modern breakthroughs in the fields of proteomics and DNA micro-arrays have widened the horizons of nanotechnology for applications with peptides and nucleic acids. Hence, biomimetic interest in the study and formulation of nanoscaled bio-structures, -materials, -devices and -therapeutic agent delivery vehicles has been recently increasing. Many of the currently–investigated functionalized bio-nanosystems draw their inspiration from naturally-occurring phenomenon, prompting the integration of molecular signals and mimicking natural processes, at the cell, tissue and organ levels. Technologically, the ability to obtain spherical nanostructures exhibiting combinations of several properties that neither individual material possesses on its own renders colloidal core-shell architectured nanosystems particularly attractive. The three main developments presently foreseen in the nanomedicine sub-arena of nanobiotechnology are: sensorization (biosensors/ biodetection), diagnosis (biomarkers/bioimaging) and drug, protein or gene delivery (systemic vs. localized/targeted controlled–release systems). Advances in bio-applications such as cell-labelling/cell membrane modelling, agent delivery and targeting, tissue engineering, organ regeneration, nanoncology and immunoassay strategies, along the major limitations and potential future and advances are highlighted in this review. Herein, is an attempt to address some of the most recent works focusing on bio-inspired and -functional polymeric-based core-shell nanoparticulate systems aimed for agent delivery. It is founded, mostly, on specialized research and review articles that have emerged during the last ten years.
Keywords: tissue engineering; quantum dots; drug delivery; dentistry; core-shell; liposomes; polymer; PLLA; biomedicine; nanoncology; nanofibers; bioimaging; biomimetic; biosensors; bone regeneration; glucose; nanoshell; artificial virus; amphiphilic co-polymers; ligand; micelles
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Cite This Article
MDPI and ACS Style
Haidar, Z.S. Bio-Inspired/-Functional Colloidal Core-Shell Polymeric-Based NanoSystems: Technology Promise in Tissue Engineering, Bioimaging and NanoMedicine. Polymers 2010, 2, 323-352.
Haidar ZS. Bio-Inspired/-Functional Colloidal Core-Shell Polymeric-Based NanoSystems: Technology Promise in Tissue Engineering, Bioimaging and NanoMedicine. Polymers. 2010; 2(3):323-352.
Haidar, Ziyad S. 2010. "Bio-Inspired/-Functional Colloidal Core-Shell Polymeric-Based NanoSystems: Technology Promise in Tissue Engineering, Bioimaging and NanoMedicine." Polymers 2, no. 3: 323-352.