Borate Minerals and RNA Stability
AbstractThe abiotic origin of genetic polymers faces two major problems: a prebiotically plausible polymerization mechanism and the maintenance of their polymerized state outside a cellular environment. The stabilizing action of borate on ribose having been reported, we have explored the possibility that borate minerals stabilize RNA. We observe that borate itself does not stabilize RNA. The analysis of a large panel of minerals tested in various physical-chemical conditions shows that in general no protection on RNA backbone is exerted, with the interesting exception of ludwigite (Mg2Fe3+BO5). Stability is a fundamental property of nucleic polymers and borate is an abundant component of the planet, hence the prebiotic interest of this analysis.
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Cossetti, C.; Crestini, C.; Saladino, R.; Mauro, E.D. Borate Minerals and RNA Stability. Polymers 2010, 2, 211-228.
Cossetti C, Crestini C, Saladino R, Mauro ED. Borate Minerals and RNA Stability. Polymers. 2010; 2(3):211-228.Chicago/Turabian Style
Cossetti, Cristina; Crestini, Claudia; Saladino, Raffaele; Mauro, Ernesto Di. 2010. "Borate Minerals and RNA Stability." Polymers 2, no. 3: 211-228.