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Polymers 2018, 10(9), 1009; https://doi.org/10.3390/polym10091009

Plasma Deposition and UV Light Induced Surface Grafting Polymerization of NIPAAm on Stainless Steel for Enhancing Corrosion Resistance and Its Drug Delivery Property

1
Department of Materials Engineering, Tatung University, Taipei 104, Taiwan
2
Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei 112, Taiwan
3
Institute of Biomedical Engineering, National Taiwan University, Taipei 106, Taiwan
4
Bachelor Program for Design and Materials for Medical Equipment and Devices, Da Yeh University, Changhua 515, Taiwan
*
Author to whom correspondence should be addressed.
Received: 10 July 2018 / Revised: 3 August 2018 / Accepted: 17 August 2018 / Published: 10 September 2018
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Abstract

When stainless steel is implanted in human bodies, the corrosion resistance and biocompatibility must be considered. In this study, first, a protective organic silicone film was coated on the surface of stainless steel by a plasma deposition technique with a precursor of hexamethyldisilazane (HMDSZ). Then, ultraviolet (UV) light-induced graft polymerization of N-isopropylacrylamide (NIPAAm) and acrylic acid (AAc) in different molar ratios were applied onto the organic silicone film in order to immobilize thermos-/pH-sensitive composite hydrogels on the surface. The thermo-/pH-sensitive composite hydrogels were tested at pH values of 4, 7.4 and 10 of a phosphate buffer saline (PBS) solution at a fixed temperature of 37 °C to observe the swelling ratio and drug delivery properties of caffeine which served as a drug delivery substance. According to the results of Fourier Transformation Infrared (FTIR) spectra and a potential polarization dynamic test, the silicone thin film formed by plasma deposition not only improved the adhesion ability between the substrate and hydrogels but also exhibited a high corrosion resistance. Furthermore, the composite hydrogels have an excellent release ratio of up to 90% of the absorbed amount after 8h at a pH of 10. In addition, the results of potential polarization dynamic tests showed that the corrosion resistance of stainless steel could be improved by the HMDSZ plasma deposition. View Full-Text
Keywords: plasma deposition; ultraviolet (UV) light; surface modification; hydrogels; drug delivery plasma deposition; ultraviolet (UV) light; surface modification; hydrogels; drug delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Chen, K.-S.; Chang, S.-J.; Feng, C.-K.; Lin, W.-L.; Liao, S.-C. Plasma Deposition and UV Light Induced Surface Grafting Polymerization of NIPAAm on Stainless Steel for Enhancing Corrosion Resistance and Its Drug Delivery Property. Polymers 2018, 10, 1009.

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