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Polymers 2018, 10(7), 732; https://doi.org/10.3390/polym10070732

Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate): Enhancement Strategies for Advanced Applications

1
Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, C/Guillem de Castro 65, 46008 Valencia, Spain
2
Facultad de Veterinaria y Ciencias Experimentales, Universidad Católica de Valencia San Vicente Mártir, C/Guillem de Castro 94, 46001 Valencia, Spain
*
Author to whom correspondence should be addressed.
Received: 5 June 2018 / Revised: 28 June 2018 / Accepted: 29 June 2018 / Published: 3 July 2018
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Abstract

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate), PHBV, is a microbial biopolymer with excellent biocompatible and biodegradable properties that make it a potential candidate for substituting petroleum-derived polymers. However, it lacks mechanical strength, water sorption and diffusion, electrical and/or thermal properties, antimicrobial activity, wettability, biological properties, and porosity, among others, limiting its application. For this reason, many researchers around the world are currently working on how to overcome the drawbacks of this promising material. This review summarises the main advances achieved in this field so far, addressing most of the chemical and physical strategies to modify PHBV and placing particular emphasis on the combination of PHBV with other materials from a variety of different structures and properties, such as other polymers, natural fibres, carbon nanomaterials, nanocellulose, nanoclays, and nanometals, producing a wide range of composite biomaterials with increased potential applications. Finally, the most important methods to fabricate porous PHBV scaffolds for tissue engineering applications are presented. Even though great advances have been achieved so far, much research needs to be conducted still, in order to find new alternative enhancement strategies able to produce advanced PHBV-based materials able to overcome many of these challenges. View Full-Text
Keywords: poly(3-hydroxybutyrate-co-3-hydroxyvalerate); mechanical strength; thermal properties; electrical properties; wettability; biological properties; antimicrobial activity; water sorption; scaffolds; advanced applications poly(3-hydroxybutyrate-co-3-hydroxyvalerate); mechanical strength; thermal properties; electrical properties; wettability; biological properties; antimicrobial activity; water sorption; scaffolds; advanced applications
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Rivera-Briso, A.L.; Serrano-Aroca, Á. Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate): Enhancement Strategies for Advanced Applications. Polymers 2018, 10, 732.

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