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Polymers 2018, 10(5), 527; https://doi.org/10.3390/polym10050527

Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications

1
Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Av. Haya de la Torre esq. Av. Medina Allende, Córdoba X5000HUA, Argentina
2
Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA), CONICET. Av. Velez Sárfield 1611, Córdoba X5000HUA, Argentina
3
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany
*
Author to whom correspondence should be addressed.
Received: 16 April 2018 / Revised: 8 May 2018 / Accepted: 9 May 2018 / Published: 14 May 2018
(This article belongs to the Special Issue Polymers for Therapy and Diagnostics)

Abstract

Hybrid nanomaterials based on inorganic nanoparticles and polymers are highly interesting structures since they combine synergistically the advantageous physical-chemical properties of both inorganic and polymeric components, providing superior functionality to the final material. These unique properties motivate the intensive study of these materials from a multidisciplinary view with the aim of finding novel applications in technological and biomedical fields. Choosing a specific synthetic methodology that allows for control over the surface composition and its architecture, enables not only the examination of the structure/property relationships, but, more importantly, the design of more efficient nanodevices for therapy and diagnosis in nanomedicine. The current review categorizes hybrid nanomaterials into three types of architectures: core-brush, hybrid nanogels, and core-shell. We focus on the analysis of the synthetic approaches that lead to the formation of each type of architecture. Furthermore, most recent advances in therapy and diagnosis applications and some inherent challenges of these materials are herein reviewed. View Full-Text
Keywords: hybrid nanomaterials; inorganic-polymeric; nano-architectures hybrid nanomaterials; inorganic-polymeric; nano-architectures
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Macchione, M.A.; Biglione, C.; Strumia, M. Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications. Polymers 2018, 10, 527.

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