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Polymers 2018, 10(5), 489; https://doi.org/10.3390/polym10050489

A Novel Delivery System for the Controlled Release~of Antimicrobial Peptides: Citropin 1.1 and Temporin A

1
Department of Biomaterials Chemistry, Chair of Inorganic and Analytical Chemistry, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, Banacha 1 St., 02-097 Warsaw, Poland
2
Department of Organic Chemistry and Biochemistry, Faculty of Materials Science and Design, Kazimierz Pulaski University of Technology and Humanities in Radom, 27 Chrobrego St., 26-600 Radom, Poland
3
Department of Environmental Health Science, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, 1 Banacha St., 02-097 Warsaw, Poland
4
Department of Inorganic Chemistry, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Gdansk, Al. Gen. J. Hallera 107 St., 80-416 Gdansk, Poland
*
Author to whom correspondence should be addressed.
Received: 16 April 2018 / Revised: 27 April 2018 / Accepted: 30 April 2018 / Published: 2 May 2018
(This article belongs to the Special Issue Biocompatible Polymers)
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Abstract

Antimicrobial peptides (AMPs) are prospective therapeutic options for treating multiple-strain infections. However, clinical and commercial development of AMPs has some limitations due to their limited stability, low bioavailability, and potential hemotoxicity. The purpose of this study was to develop new polymeric carriers as highly controlled release devices for amphibian peptides citropin 1.1 (CIT) and temporin A (TEMP). The release rate of the active pharmaceutical ingredients (APIs) was strongly dependent on the API characteristics and the matrix microstructure. In the current work, we investigated the effect of the polymer microstructure on in vitro release kinetics of AMPs. Non-contact laser profilometry, scanning electron microscopy (SEM), and differential scanning calorimetry (DSC) were used to determine the structural changes during matrix degradation. Moreover, geno- and cytotoxicity of the synthesized new carriers were evaluated. The in vitro release study of AMPs from the obtained non-toxic matrices shows that peptides were released with near-zero-order kinetics. The peptide “burst release” effect was not observed. New devices have reached the therapeutic concentration of AMPs within 24 h and maintained it for 28 days. Hence, our results suggest that these polymeric devices could be potentially used as therapeutic options for the treatment of local infections. View Full-Text
Keywords: antimicrobial peptides; biodegradable polymers; biocompatible polymers; drug delivery systems; controlled release; citropin; temporin; ionic liquids antimicrobial peptides; biodegradable polymers; biocompatible polymers; drug delivery systems; controlled release; citropin; temporin; ionic liquids
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Piotrowska, U.; Oledzka, E.; Zgadzaj, A.; Bauer, M.; Sobczak, M. A Novel Delivery System for the Controlled Release~of Antimicrobial Peptides: Citropin 1.1 and Temporin A. Polymers 2018, 10, 489.

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