Next Article in Journal
Effects of Graphene Nanoplatelet Size and Surface Area on the AC Electrical Conductivity and Dielectric Constant of Epoxy Nanocomposites
Previous Article in Journal
Coarse-Grained Simulations of Aqueous Thermoresponsive Polyethers
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessArticle
Polymers 2018, 10(5), 476; https://doi.org/10.3390/polym10050476

New Insight into Polydopamine@ZIF-8 Nanohybrids: A Zinc-Releasing Container for Potential Anticancer Activity

1
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
2
School of Chemical Engineering, Guizhou Institute of Technology, Guiyang 550003, China
3
Basic Medical Experimental Teaching Center, School of Basic Medical Science, Guizhou Medical University, Guiyang 550025, China
4
The State Key Laboratories of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research Co. Ltd., Tianjin 300193, China
5
Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
6
School of Biology and Engineering, Guizhou Medical University, Guiyang 550025, China
7
School of Pharmaceutical Science, Guizhou Medical University, Guiyang 550025, China
*
Authors to whom correspondence should be addressed.
Received: 19 March 2018 / Revised: 22 April 2018 / Accepted: 23 April 2018 / Published: 27 April 2018
(This article belongs to the Special Issue Nanostructured Polymers and Nanocomposites)
View Full-Text   |   Download PDF [3939 KB, uploaded 3 May 2018]   |  

Abstract

Despite the initial evidence on the role of zinc and zinc transporters in cancer prevention, little attention has been paid to the zinc-derived compounds. In the present work, we reported a strategy to prepare a kind of zinc-releasing container with enhanced biocompatibility and release dynamics using ZIF-8 nanocrystals as the sacrificial templates. Transmission electron microscopy (TEM) analysis demonstrated that the ZIF-8 nanocrystals were gradually etched out in the aqueous media within 48 h, resulting in hollow nanocapsules. Notably, we found the self-polymerization of dopamine can form nanoshells around the ZIF-8 nanocrystals, which served as a type of functional membranes during the release of zinc. More interestingly, PDA@ZIF-8–based nanohybrids expressed stronger inhibition to the cancer cell growth, which implied that the nanohybrids could be a drug carrier for chemotherapy. This study broadens the biomedical application of ZIF-8 and also provides a versatile strategy toward the development of multifunctional delivery system. View Full-Text
Keywords: polydopamine; ZIF-8; Zinc-releasing; anticancer activity polydopamine; ZIF-8; Zinc-releasing; anticancer activity
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Ran, J.; Wang, C.; Zhang, J.; Wang, W.; Xiao, L.; Jia, S.; Wang, Z.; Wu, W.; Xiao, J.; Wu, X. New Insight into Polydopamine@ZIF-8 Nanohybrids: A Zinc-Releasing Container for Potential Anticancer Activity. Polymers 2018, 10, 476.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top