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Polymers 2018, 10(4), 455; https://doi.org/10.3390/polym10040455

New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications

1
Pharmaceutics & Polymeric Drug Delivery Research Laboratory, College of Pharmacy, Qatar University, P.O. Box 2713, Doha, Qatar
2
Anti-Doping Lab Qatar, Sports City Road, P.O. Box 2713, Doha, Qatar
3
Faculty of Biomedical Sciences, School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TH, UK
4
Office of Vice President for Research & Graduate Studies, Qatar University, P.O. Box 2713, Doha, Qatar
*
Author to whom correspondence should be addressed.
Received: 29 March 2018 / Revised: 15 April 2018 / Accepted: 17 April 2018 / Published: 19 April 2018
(This article belongs to the Special Issue Elastomers)
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Abstract

Reactive electrospinning is capable of efficiently producing in situ crosslinked scaffolds resembling the natural extracellular matrix with tunable characteristics. In this study, we aimed to synthesize, characterize, and investigate the in vitro cytocompatibility of electrospun fibers of acrylated poly(1,10-decanediol-co-tricarballylate) copolymer prepared utilizing the photoreactive electrospinning process with ultraviolet radiation for crosslinking, to be used for cardiac tissue engineering applications. Chemical, thermal, and morphological characterization confirmed the successful synthesis of the polymer used for production of the electrospun fibrous scaffolds with more than 70% porosity. Mechanical testing confirmed the elastomeric nature of the fibers required to withstand cardiac contraction and relaxation. The cell viability assay showed no significant cytotoxicity of the fibers on cultured cardiomyoblasts and the cell-scaffolds interaction study showed a significant increase in cell attachment and growth on the electrospun fibers compared to the reference. This data suggests that the newly synthesized fibrous scaffold constitutes a promising candidate for cardiac tissue engineering applications. View Full-Text
Keywords: poly(diol-tricarballylate); reactive electrospinning; particulate leaching; photo-crosslinking; cardiac tissue engineering; biocompatibility poly(diol-tricarballylate); reactive electrospinning; particulate leaching; photo-crosslinking; cardiac tissue engineering; biocompatibility
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ismail, H.M.; Zamani, S.; Elrayess, M.A.; Kafienah, W.; Younes, H.M. New Three-Dimensional Poly(decanediol-co-tricarballylate) Elastomeric Fibrous Mesh Fabricated by Photoreactive Electrospinning for Cardiac Tissue Engineering Applications. Polymers 2018, 10, 455.

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