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Polymers 2018, 10(3), 309; https://doi.org/10.3390/polym10030309

Synthesis, Characterization and Drug Loading of Multiresponsive p[NIPAm-co-PEGMA] (core)/p[NIPAm-co-AAc] (Shell) Nanogels with Monodisperse Size Distributions

1
Department of Chemistry, Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway
2
Ugelstad Laboratory, Department of Chemical Engineering, Norwegian University of Science and Technology (NTNU), N-7491 Trondheim, Norway
3
Polymer Particles and Surface Chemistry Research Group, SINTEF Industry, N-7465 Trondheim, Norway
*
Authors to whom correspondence should be addressed.
Received: 19 February 2018 / Revised: 8 March 2018 / Accepted: 12 March 2018 / Published: 13 March 2018
(This article belongs to the Special Issue Core-Shell Structured Polymers)
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Abstract

We report the synthesis and properties of temperature- and pH-responsive p([NIPAm-co-PEGMA] (core)/[NIPAm-co-AAc] (shell)) nanogels with narrow size distributions, tunable sizes and increased drug loading efficiencies. The core-shell nanogels were synthesized using an optimized two-stage seeded polymerization methodology. The core-shell nanogels show a narrow size distribution and controllable physico-chemical properties. The hydrodynamic sizes, charge distributions, temperature-induced volume phase transition behaviors, pH-responsive behaviors and drug loading capabilities of the core-shell nanogels were investigated using transmission electron microscopy, zeta potential measurements, dynamic light scattering and UV-Vis spectroscopy. The size of the core-shell nanogels was controlled by polymerizing NIPAm with crosslinker poly(ethylene glycol) dimethacrylate (PEGDMA) of different molecular weights (Mn-200, 400, 550 and 750 g/mol) during the core synthesis. It was found that the swelling/deswelling kinetics of the nanogels was sharp and reversible; with its volume phase transition temperature in the range of 40–42 °C. Furthermore, the nanogels loaded with l-3,4-dihydroxyphenylalanine (L-DOPA), using a modified breathing-in mechanism, showed high loading and encapsulation efficiencies, providing potential possibilities of such nanogels for biomedical applications. View Full-Text
Keywords: pNIPAm; crosslinker; monodispersity; VPTT; core-shell; L-DOPA pNIPAm; crosslinker; monodispersity; VPTT; core-shell; L-DOPA
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Raju, R.; Bandyopadhyay, S.; Sharma, A.; Gonzalez, S.V.; Carlsen, P.H.; Gautun, O.R.; Glomm, W.R. Synthesis, Characterization and Drug Loading of Multiresponsive p[NIPAm-co-PEGMA] (core)/p[NIPAm-co-AAc] (Shell) Nanogels with Monodisperse Size Distributions. Polymers 2018, 10, 309.

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