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Polymers 2018, 10(3), 297; https://doi.org/10.3390/polym10030297

The Discovery of an Iridium(III) Dimer Complex as a Potent Antibacterial Agent against Non-Replicating Mycobacterium smegmatis

1
Institute of Modern Biopharmaceuticals, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China
2
College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, Henan, China
3
School of Pharmacy, Chongqing Medical and Pharmaceutical College, Chongqing 401331, China
*
Authors to whom correspondence should be addressed.
Received: 12 February 2018 / Revised: 4 March 2018 / Accepted: 6 March 2018 / Published: 9 March 2018
(This article belongs to the Special Issue Antimicrobial Polymers)
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Abstract

Novel agents are urgently needed to rapidly kill drug-resistant Mycobacterium tuberculosis. Noble metal complexes, particularly polypyridyl iridium complexes serving as therapeutic agents, have attracted considerable interest recently, due to their significant cytotoxic or antimicrobial activities. Here, we reported an polypyridyl iridium dimer complex [Ir(ppy)2Cl]2 (3), with ppy = phenylpyridine, which was found to be active against both exponential growing and non-replicating M. smegmatis, with minimum inhibitory concentration values of 2 μg/mL, and exhibited rapid bactericidal kinetics, killing pathogens within 30–60 min. Moreover, 3 was demonstrated to generate a large amount of reactive oxygen species and to be effective in drug-resistant strains. Taken together, the selectively active iridium(III) dimer complex showed promise for use as a novel drug candidate for the treatment of M. tuberculosis infection. View Full-Text
Keywords: M. tuberculosis; iridium dimer complex; bactericidal; ROS; non-replicating M. tuberculosis; iridium dimer complex; bactericidal; ROS; non-replicating
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Liao, G.; Peng, X.; Li, T.; Ye, Z.; Xiang, X.; Fu, C. The Discovery of an Iridium(III) Dimer Complex as a Potent Antibacterial Agent against Non-Replicating Mycobacterium smegmatis. Polymers 2018, 10, 297.

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